摘要
目的考察鸡新城疫病毒Ⅳ系(newcastlediseasevirusⅣ,NDVⅣ)活疫苗作为辅助治疗手段用于人类鼻咽癌患者的安全性、免疫学效应和临床效果。方法以NDVLaSota株制备活疫苗,以喷雾吸入途径接种于家兔,观察其安全性及免疫学效果;之后,再以相同途径接种于放射治疗后的鼻咽癌患者,观察其安全性、免疫学效果和辅助治疗的临床效果。结果接种该疫苗之后,实验动物和鼻咽癌患者的近期毒副发应都属轻微,未见严重肝肾功能损害;血清均可测出相应的抗体,其几何平均滴度随接种程序的推进而相应升高;接种该疫苗的鼻咽癌患者,其3年复发率、5年复发率均明显低于对照组(分别为3.23%vs25.81%;12.36%vs33.72%),差异均有统计学意义。结论鸡新城疫病毒Ⅳ系活疫苗接种于实验动物家兔和人,都具有良好的安全性;都能产生明显的免疫学效应;用于放射治疗后的鼻烟癌患者,能明显减少其治疗后复发率。
Objective To observe the safety, immunological effect, and clinical effect of new casde disease finis IV vaccine （NDV Ⅳ vaccine） when it was used as a supplement to cure the patients with NPC. Methods NDV La Sota vaccine was first used to rabbits, by means of spraying,to observe it＇s safety,immunological effect. After then,the vaccine was used to the patients with NPC who had been had a radiotherapy, also by means of spraying. Results The vaccine, no matter being used in experimental animals or in NPC patients, side effects, ff any, were all slight and gende. No severe injury on liver or renal functions was found. Responsive antibodies could be detected in serum samples from experimental animals as well as from NPC patients, the more the times the vaccine being used, the higher titers would be seen in the serum. The relapse rates in 3 years or 5 years were obviously lower in patients who had been vaccine-treated than that in control patients （3.23 % vs 25.81 % and 12.36 % vs 33.72 %,respeetively）. These differences had statistically signifieanee.Condusion NDV Ⅳ vaccine had good safety, could initiate obvious immunological effects,when it was used in rabbits as well as in human-being. NPC relapse rate in patients who had been had a radiotherapy could be obviously lower down ffthe vaccine was used. So that, in clinical practicc,this vaccine could be used as a supplement to cure such patients.
出处
《广西医学》
CAS
2005年第11期1716-1719,共4页
Guangxi Medical Journal
基金
广西壮族自治区卫生厅科研资助项目(桂卫科Z200040)
关键词
NDV
Ⅳ疫苗
免疫治疗
鼻咽肿瘤
NDV Ⅳ vaccine
Inhaling vaccination
Immunotherapy
