摘要
目的探讨炎症因子C-反应蛋白(CRP)与胰岛素抵抗(IR)和2型糖尿病(T2DM)大血管病变的关系。方法用颗粒增强免疫沉淀法测定T2DM合并大血管病变(70例)、T2DM无大血管病变(60例)及正常对照组(90名)的血清超敏CRP(usCRP)水平变化;用HOMA-IR模型作为估计IR 的指标;将CRP与HOMA-IR、空腹胰岛素(FINS)、同型半胱氨酸(Hcy)、空腹血糖(FBG)、体重指数(BMI)、腰臀比(WHR)、甘油三酯(TG)等作相关分析。结果T2DM合并大血管病变组血清usCRP 水平明显高于T2DM无大血管病变组及正常对照组(P<0.01),T2DM无大血管病变组高于正常对照组(P<0.01)。当调整SBP、FBG、TG、WHR等因素的影响后,协方差结果显示usCRP在T2DM合并大血管病变组仍高于T2DM无大血管病变组及正常对照组(P<0.05),T2DM无大血管病变组高于正常对照组(P<0.05)。在T2DM合并大血管病变组,Person相关分析显示,useCRP与FINS、HOMA-IR、TG呈正相关(P值分别<0.05、<0.01和<0.05),与Hcy等无关。逐步线性回归结果显示,TG、HOMA-IR是影响CRP的主要因素。结论CRP可能是T2DM和T2DM大血管病变的危险因子,CRP可能通过胰岛素抵抗参与了T2DM大血管病变的发生和发展。
Objective To study the possible association between C-reactive （CRP） and insulin resistance（IR） as well as the pathogenesis of type 2 diabetes macrovascular complication. Methods Serum CRP was measured by uhrasensitive immuoturbidimetric, which was determined on type 2 diabetes （T2DM） with or without macrovascular complication（70 and 60 cases respectively） and on normal controls （90 cases）. IR was estimated by homeostasis model assessment（HOMA-IR）. Results Resuhs showed that the concentration of CRP was higher in T2DM with or without macrovascular complications than that in the healthy subjects （P〈 0.01）, while it was higher in diabetic patients with macrovascular complications than that in diabetic patients without macrovascular complications （P〈 0.01 ）. In diabetic patients with macrovascular complications, person correlation analysis indicated that there existed positive correlations between CRP and FINS, HOMA-IR, triglyceride（TG） while stepwise linear regression showed that usCRP and HOMA-IR, TG having linear correlation. Conclusion CRP seemed to play a role in the initiation and progression of atherosclerosis in type 2 diabetes, possibly was by the way of IR.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2005年第10期804-807,共4页
Chinese Journal of Epidemiology
关键词
糖尿病
2型
C反应蛋白
大血管病变
胰岛素抵抗
Diabetes, type 2
Ultrasensitive C-reactive protein
Macrovascular complications
Insulin resistance
