摘要
目的:研究食物对复方缬沙坦片中缬沙坦人体药动学的影响。方法:采用随机交叉试验设计,10名男性健康志愿者禁食12 h后空腹或进食后口服复方缬沙坦片2片(每片含缬沙坦80 mg),反相高效液相色谱法测定血浆中缬沙坦的浓度。结果:受试者空腹和进食后口服复方缬沙坦片,血浆中缬沙坦的主要药动学参数:Cmax分别为(4．238±0．822)和(2．984± 1.230)mg·L-1,Imax分别为(2.70±0．63)和(3．20±1.38)h,AUC0→∞分别为(32．06±7.14)和(25．39±7．60)mg·h·L-1,CL分别为(5.247±1.310)和(6．981±2.623)L·h-1。结论:食物对缬沙坦的药代动力学特征有显著影响。
Objective： The food on influences of the pharmacokinetics of valsartan in compound valsartan tablets was studied. Method： 10 healthy male subjects received two tablets of the compound valsartan （containing valsartan 80 mg per tablet）, once after a 12 hour fast, and once following a standard high-fat meal at random crossover design. Plasma samples of valsartan obtained periodically were determined using an RP-HPLC method. Result： Under fasted and fed conditions, the main pharmacokinetic parameters of valsartan was as follows： Cmax were （4. 238 ±0.822） and （2. 984 ± 1. 230） mg·L^-1 ,tmax were （2.70 ±0.63） and （3.20 ± 1.38） h,AUC0→∞ were （32. 06 ± 7.14） and （25.39 ± 7.60） mg·h·L^-1 ,CL were （5. 247 ± 1. 310） and （6. 981 ± 2. 623） L·h^-1. Conclusion： Food had a statistically significant effect on the pharmacokinetics of valsartan.
出处
《中国药师》
CAS
2005年第12期988-990,共3页
China Pharmacist
