摘要
目的探讨炎症介质在急性胰腺炎(AP)发病机制中的作用。方法观察AP大鼠血清TNF,IL-6与胰腺的病理组织学变化的关系。结果(1)假手术组动物始终存活,胰腺炎组生存时间明显缩短(P<0.0 5);2 4 h死亡率显著升高(P<0.0 5);(2)胰腺炎组2 4 h死亡率与TNF-α浓度呈正相关(γ=0.9 9 7 2,P<0.0 5),TNF-α浓度越高,大鼠死亡率越高;(3)胰腺炎组的TNF-α和IL-6浓度随AP后时间的延长进行性升高,与假手术组相比有极显著性差异(P<0.0 1)。各时间点假手术组的胰腺病理评分均显著低于胰腺炎组(均P<0.0 5)。结论TNF,IL-6的激活在胰腺炎的发生和发展过程有重要作用。
Objective To explore the role of inflammatory mediators in the pathogenesis of acute pancreatitis （AP）. Methods Observation the relationship betweent the changes in serum TNF and IL-6 and histopathology of the pancreas in AP rats. Results （ 1 ） Rats in sham operation group survived throughout the experiment. Compared with of sham operation group, in AP group survival time shortened significantly （ P 〈0. 05 ） and 24h death rate increased significantly （ P 〈0. 05 ） ; （ 2 ） There existed a positive correlation between death rate and TNF concentration in AP group at 24h （r =0. 9972, P 〈0. 05） ; （3） The concentration of TNF-α and IL-6 increased significantly with post operative time in AP group（ P 〈0.01 ） , and the pathologic score of pencreas in sham group was significantly lower than AP group at each time point （ all P 〈0. 05 ） . Conclusions The activation of TNF and IL-6 plays an important role in the pathogenesis of AP.
出处
《中国普通外科杂志》
CAS
CSCD
2005年第11期828-830,共3页
China Journal of General Surgery
