摘要
目的:探讨固本延衰方延缓亚急性衰老模型小鼠衰老的机制。方法:将60只小鼠随机分为4组,除正常对照组外均皮下注射D-半乳糖造成衰老模型,并给予不同剂量的固本延衰方治疗,分别用放免法及流式法测定脾淋巴细胞白细胞介素2及其受体水平。结果:衰老模型组IL-2及其受体水平明显低于正常对照组(P<0.05),固本延衰方各剂量组IL-2及其受体水平明显高于衰老模型组(P<0.05,P<0.01)。结论:提示固本延衰方通过提高衰老机体淋巴细胞IL-2及其受体表达水平,从而调节机体免疫功能延缓衰老。
Objective： To research the mechanism of GuBenYanShuai recipe to postpone the senescence of the subacute aging modle mice. Methd： divide 60 mices into 4 groups, make aging model using D - glucose subcutaneous injection except the control group. After theraping with different dosage GBYSR detect the spleen lymphocyte IL - 2 and IL - 2R in radio - immunity assay and Flow cells assay respectivly. Result： the level of Ⅱ - 2 and IL- 2R in model group is lower than control group （ P 〈 0.05）, the level of Ⅱ - 2 in maximums dosage of GBYSR group is higher than model group （P 〈0.05, P 〈0.01）. Conclution： imply that GBYSR could postpone aging from improving the level of IL- 2 then regulating the body＇s immune function.
出处
《云南中医学院学报》
2005年第4期40-42,共3页
Journal of Yunnan University of Traditional Chinese Medicine
基金
湖北省教育厅资助青年课题(NO:2003B00001)
湖北省卫生厅资助课题
