摘要
Three isomalabaricane and malabaricane triterpenoids（1-3） were isolated from the sponge Stelletta sp.collected from Weizhou Island,Guangxi Province.The structures of compounds 1-3 were identified mainly by spectroscopic methods and X-ray diffraction analysis.All 1H NMR and 13C NMR signals of compound 1 were assigned for the first time on the basis of HMQC,<sup>1H-<sup>1H COSY and HMBC experiment.Antitumor assay exhibits that compounds 1,2 and 3 have a significant antitumor activity against P388 tumor cell lines with ED50 values 0.01,0.5,1.0 μg/mL,respectively.
Three isomalabaricane and malabaricane triterpenoids （1-3） were isolated from the sponge Stelletta sp. collected from Weizhou Island, Guangxi Province. The structures of compounds 1-3 were identified mainly by spectroscopic methods and X-ray diffraction analysis. All I H NMR and ^13C NMR signals of compound 1 were assigned for the first time on the basis of HMQC, ^1H-^1H COSY and HMBC experiment. Antitumor assay exhibits that compounds 1, 2 and 3 have a significant antitumor activity against P388 tumor cell lines with EDso values 0.01, 0.5, 1.0μg/mL, respectively.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2005年第12期2270-2272,共3页
Chemical Journal of Chinese Universities
基金
国家高科技发展项目(海洋"八六三"计划)(批准号:2001AA620403)
广西省自然科学基金(批准号:0144002)资助
关键词
海绵
星骨属海绵
三萜化合物
抗肿瘤
Sponge
Stelletta sp.
Triterpenoid
Antitumor activity
