摘要
目的:观察电针改善家兔椎基底动脉供血不足内耳微循环障碍所致颈源性眩晕的效果,并与氟桂利嗪进行阳性对照。方法:取64只日本大耳兔随机分为对照组、模型组、电针组和氟桂利嗪组4组,每组16只。①造模:200 g／L组织硬化剂-775注射液10 mL注射至模型组、电针组和氟桂利嗪组左侧颈椎横突软组织,建立椎动脉型颈椎病模型,对照组注射生理盐水。②治疗:注射后第6周开始,电针组作双侧“风池”“听宫”“外关”穴电针处理(峰值电压4-6V,刺激频率10 Hz), 氟桂利嗪组以氟桂利嗪1．67 mg／kg进行胃灌注,1次/d,连续14 d,其他两组不干预。③观察指标:平行秋千分别产生±0．17 G、±0．34 G和±0．5 G 直线加速度刺激家兔前庭,测定诱发的眼震电图频率;经颅多普勒检测基底动脉和左、右侧椎动脉收缩期、舒张期和平均血流速度;激光多谱勒血流计检测左侧内耳血流量。结果:37只兔进入结果分析。①眼震电图频率:对照组±0．5 G直线加速度诱发的显著高于±0．17 G(P<0．05)。模型组、氟桂利嗪组3种直线加速度和电针组±0．5 G直线加速度诱发眼震电图频率均显著低于对照组(P<0．05- 0．001)。电针组3种直线加速度和氟桂利嗪组±0．5 G诱发眼震电图频率显著高于模型组(P<0．01-0．001)。②血流速度:模型组左、右侧椎动脉及基底动脉、氟桂利嗪组左、右侧椎动脉的收缩期、舒张期和平均血流速度均较对照组显著减慢(P<0．01-0．001),电针组左侧椎动脉和氟桂利嗪组基底动脉的收缩期血流速度与对照组无显著差异(P>0．05),电针组左和右侧椎动脉的舒张期血流速度显著快于氟桂利嗪组(P<0．05)。③内耳血流量:模型组和氟桂利嗪组显著低于对照组(P<0．001,0．05),电针组和氟桂利嗪组显著高于模型组(P<0．001,P<0．01),电针组与对照组无差异(P>0．05)。结论:电针可改善椎基底动脉供血不足,并通过增强内耳微循环局部调节改善内耳血供和前庭-眼反射,恢复前庭功能。其效应优于氟桂利嗪。
AIM： To observe the effects of electroacupuneture on ameliorating cervical vertigo induced by microeireulation obstruction of inner ear in rabbits with vertebrobasilar insufficiency （VBI）, and perform positive control with flunarizine. METHODS：Sixty-four rabbits with big ear were selected and divided into： control group, model group, electroaeupuncture group and flunarizine group with 16 rats in each group. ① Molding： The rabbits in the model group, the electroaeupuncture group and the flunarizine group were injected with 200 g/L tissue sclerosing-775 injection 10 mL into the soft tissue on the left side of transverse processes of cervical vertebral to set up the vertebral artery type of cervical spondylosis （VCS） models, and those in the control group was injected with saline. ②Treatment： From the 6^th weeks after injecting, acupuncture points at bilateral “Fengchi （GB 20）”, “Tingkong （SI 19）”and “W aikuan （SJ 5）”were administered to the rabbits in the electroacupuncture group at double side （4-6 V peak voltage, 10 Hz frequency of stimulation）. The rabbits in the flunarizine group were treated with 1.67 mg/kg flunarizine with gastric perfusion, once a day for 14 days. No treatment in the other group. ③ Observing indexes： The freguencies of eleetronystagmography （ENG） induced by linear accelerations of±0.17 G, ±0.34 G and±0.5 G, respectively with a parallel-swing stimulating to the rabbils vestibules. The systolic phase velocity （Vs）, diastolic phase velocity （Vd） and mean velocity （Vm） of blood flow in the basilar artery, the left and fight side of vertebrarteries （LVA, RVA） were measured with transcranial Doppler （TCD）. The inner ear blood flow （IEBF） at left side was measured with the laser Doppler flowmetry （LDF）. RESULTS： Thirty-seven rabbits were involved in the result analysis.①Frequencies of ENG： The frequency of ENG induced by ±0.5 G linear acceleration was significantly higher than that by ±0.17 G in the control group. The frequencies of ENG induced ny three kinds of linear accelerations in the model group and flunarizine group as well as that by ±0.5 G linear acceleration in the electroacupuneture group were significantly lower than those in the control group（P〈 0.05-0.001 ）. The frequencies of ENG induced by three kinds of linear accelerations in the eleetroacupuncture group and that by ~0.5 G linear acceleration in the flunarizine group were significantly higher than those in the model group （P〈 0.01-0.001 ）. ②Hemodynamics：LVA, RVA and basilar artery in the model group, Vs,Vd and Vm of LVA and RVA in the flunarizine group reduced distinctly ascompared with the control group（P〈 0.01-0.001 ）. There was no notable difference of LVA in the electroacupuncture group and Vs of basilar artery in the flunarizine group with those in the control group （P 〉 0.05）. Vd of LVA and RVA in the electroacupuncture group was obviously quick than those of in the flunarizine group （P 〈 0.05）. ③ IEBF： IEBF in the model group and the flunarizine group were evidently lower than that in the control group （P〈0.001, 0.05）. IEBF in the electroacupuncture group and the flunarizine group were observably higher than that in the model group（P 〈 0.001, P〈0.01）, and there was no difference between the electroacupuncture group and the control group （P〉 0.05）. CONCLUSION： The electroacupuncture can improve VBI, ameliorate inner ear blood supply and the vestibulo-ocular reflex depending upon enhancing local adjusting fur inner ear microcirculation to recovery vestibular function. Its effects are superior to those of flunarizine.
出处
《中国临床康复》
CAS
CSCD
北大核心
2005年第41期90-93,共4页
Chinese Journal of Clinical Rehabilitation
基金
四川省教育厅自然科学基金资助项目(01LC11)
