摘要
为探讨血浆PGI_2水平与肝损害和门脉高压的关系,我们观察了胆管结扎犬肝硬化模型在肝硬化形成过程中外周血PGI_2水平的动态变化及其与肝功能和门脉压力的相关性.结果表明,在实验过程中(第0、1、3、5、7、9周).动物血浆PGI_2水平进行性升高(13.30±6.95、82.54±71.58、108.40±77.15、166.13±71.80、173.15±124.10和209.56±151.63pg/ml,P<0.01),且与血清白蛋白水平呈负相关(r=-0.88,P<0.01).与基础门脉压呈正相关(r=-0.71,P<0.05).由此可见,胆管结扎犬血浆PGI_2的代谢与肝损害和门脉高压之间可能存在某种因果联系.
To ascertain the relation ot prostacyclin to liver injury and portal hypertension in dogs with cirrhosis induced by chronic bile-duct-ligation, the present study was conducted. The results showed that, before and week 1,3,5,7, and 9 after bile-duct-ligation, plasma 6-keto-PGF1α levels of the dogs were progressively increased (13.30±6.95, 82.54±72.58,108.40 ± 77.15,166.13±71.80,173.15± 124.10 and 209.56±151.63 pg/ml, respectively, P<(0.01), of which three peak values occurred in week 1,5,9, particularly. In the course of development of cirrhosis, there was no correlation between 6-ke-to-PGF1α levels and serum bilirubin, ALT or AST. There was a negative correlation between 6-keto-PGF1α and serum albumin level (r =-0.88, P<0.01). The basal level of 6-keto-PGF1α was related to portal pressure (r = 0.71,P<0.05), however after the formation of cirrhosis, no association between 6-keto-PGF1α and portal pressure was found. We conclude that prostacyclin may play an important role in the pathogenesis of portal pressure of the cirrhotic dogs with chronic bile-duct-ligation.
出处
《临床消化病杂志》
1996年第2期49-53,共5页
Chinese Journal of Clinical Gastroenterology
关键词
门脉高压
前列环素
胆管结扎
肝硬变
Chronic bile-duct-ligation Liver cirrhosis Portal hypertension Prostacyclin
