摘要
目的探讨透明质酸口服吸收的机制。方法采用放射免疫法测定大鼠单剂量口服透明质酸溶液和3种单糖(D-葡糖 醛酸、N-乙酰氨基葡糖及两者等摩尔配比)溶液后血清中透明质酸的浓度,用梯形法计算AUC。结果 生理盐水对照组和D- 葡糖醛酸组的血清中透明质酸没有出现峰值;透明质酸组在口服后约2 h,出现明显的透明质酸吸收峰;另外两个单糖组在口 服后7 h左右,出现一个明显的透明质酸合成峰。透明质酸组的AUC0-13 h为2 417μg·h·L-1,实测ρmax为187．6μg·L-1,tmax为 2．0 h。结论透明质酸口服后可以被机体吸收,且部分能以非单糖的形式被机体吸收。
OBJECTIVE To study the absorption of hyaluronic acid （HA） administrated orally in rats METHODS The concentrations of HA in rats serum were determined by the radioimmumoassay after a single dose of HA and three monosaccharides （ D-glucuronic acid, N- aeetylglueosamine and the equal mole ratio of both） were administered orally. The AUC was calculated by trapezoidal integration. RFSULTS There were no evident changes with the serum HA levels in both of saline group and D-glucuronic acid group. The sorum HA levels in HA group appeared an absorption peak at 2 h ＇after an oral adninistration. The sorum HA levels of other monosaccharides groups appeared a synthetic peak of HA at about 7 h after an oral adninistration. The main pharmacokinetic parameters of HA were as follows： AUC0-13 2 417 μg·h·L^-1, ρmax187.6μg·L^-1, tmax 2.0 h. CONCLUSION HA is absorbed and partial HA is absorbed as the form of non-monosaecharide after an oral administration.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2005年第23期1811-1813,共3页
Chinese Pharmaceutical Journal
关键词
透明质酸
口服
药动学
放射免疫测定
hyaluronic acid
oral administration
pharmacokinetics
radioimmunoassay
