摘要
A spectrophotometric method for the determination of azithromycin has been developed based on the charge transfer reaction.The reaction between azithromycin and 7,7,8,8-tetracyanoquinodemethane（（TCNQ）） was completed in acetone medium in 30 minutes at 50 ℃.Beer′s law is obeyed in the range of（12.1）867.6 mg/L for the determination of azithromycin.The molar absorptivity of the complex at 745 nm is 1.44×103 L/（mol·cm）.The relative standard deviation is 0.96%（n=10）.The composition ratio of the charge transfer complex was found to be 1∶[KG-*3/5]1 by means of the slope ratio and Job′s methods.This method has been applied to the determination of azithromycin in tablets with satisfactory results compared with the Pharmacopoeia method.Recovery was 100.5%.
A spectrophotometric method for the determination of azithromycin has been developed based on the charge transfer reaction. The reaction between azithromycin and 7,7, 8,8-tetracyanoquinodemethane （TCNQ） was completed in acetone medium in 30 minutes at 50℃. Beer＇s law is obeyed in the range of 12. 1 -867.6 mg/L for the determination of azithromycin. The molar absorptivity of the complex at 745 nm is 1.44 × 103 L/（ mol ·cm）. The relative standard deviation is 0. 96% （n = 10 ）. The composition ratio of the charge transfer complex was found to be 1：1 by means of the slope ratio and Job＇s methods. This method has been applied to the determination of azithromycin in tablets with satisfactory results compared with the Pharmacopoeia method. Recovery was 100. 5%.
出处
《应用化学》
CAS
CSCD
北大核心
2005年第12期1363-1365,共3页
Chinese Journal of Applied Chemistry
基金
中国科学院方向项目(KJZX3-SW-121)
广东省自然科学基金团队项目(20003046)资助
关键词
荷移反应
分光光度
TCNQ
阿奇霉素
charge transfer reaction, spectrophtometry, azithromycin, tetracyanoquinodemethane
