摘要
目的:探讨胃腺癌组织中胰岛素样生长因子Ⅰ(IGFⅠ)的表达及其与胃腺癌发生发展的关系。方法:应用免疫组织化学方法,检测56例胃腺癌组织(浸润至黏膜层3例,黏膜下层12例,肌层27例,浆膜层14例;有淋巴结转移者34例,无淋巴结转移者22例;TNM分期Ⅰ期4例,Ⅱ期16例,Ⅲ期24例,Ⅳ期12例)、40例癌旁不典型增生组织和56例正常胃组织中IGFⅠ的表达,并分析IGFⅠ表达与胃腺癌临床病理特征的关系。结果:胃癌组织、癌旁不典型增生组织及正常胃黏膜组织中IGFⅠ的阳性表达率分别为85.71%、55.00%和17.86%,3组间两两比较,差异均有统计学意义(P<0.05);IGFⅠ与胃腺癌的浸润深度、淋巴结转移、病理分期及分化程度有关(P<0.05或0.01)。结论:IGFⅠ在胃腺癌组织中高表达与胃腺癌的发生发展及浸润转移有关。
Aim ： To investigate the expression of insulin-like growth factor-1 （IGF-Ⅰ ） in garstric adenocarcinoma tissue. Methods： The expression of IGF-Ⅰ in 56 cases of gastric adenocarcinoma, 40 cases of atypical hyperplasia of adjacent cancer, and 56 cases of normal garstric tissue was detected using immunohistochemistry. Results： The positive rates of IGF-Ⅰ in gastric carcinoma tissue, atypical hyperplasia tissue and normal gastric mucous tissue were 85,71% ,55, 00% and 17, 86% , respectively, and the difference between any 2 groups was significant （P 〈 0.05） ;IGF-Ⅰ was correlated with the degree of the invasion, differentiation, lymphatic metastasis, and pathological stages of gastric adenocarcinoma （P 〈 0.05 or 0.01 ）, Conclusion： The overexpression of IGF-Ⅰ in gastric adenocarcinoma tissue is correlated with the pathogenesis,development,invasion and metastasis of gastric adenocarcinoma.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2005年第6期1117-1119,共3页
Journal of Zhengzhou University(Medical Sciences)
关键词
胰岛素样生长因子-1
胃肿瘤
浸润
转移
insulin-like growth factor-l
gastric neoplasm
invasion
metastasis
