摘要
[目的]研究中药开口箭有效成分对实验性结肠炎大鼠血小板活性的影响。[方法]建立三硝基苯磺酸大鼠结肠炎模型,用开口箭醇提物(主要成分为甾体皂苷)灌肠治疗2周后评价大鼠血小板表面P-选择素以及血小板聚集率改变。[结果]治疗组与模型组比较,血小板聚集率和血小板表面P-选择素下降(P<0.05)。[结论]开口箭醇提物可以抑制血小板的聚集与活化。
[Objective]To study the effect of effectual component of tupistra chinensis on the platelet activity of rats colitis model. [Methods] The rat model Of colitis was induced by trinitrobenzene-sulfonic acid （TNBS）, then treated with tupistra chinensis for two weeks. At the end of the experiment, the quantity of P-selectin on platelet and platelet aggregability （Pag） were detected. [Results] P-selectin on platelet and Pag of treatment group were lower than those of control group. [Conclusion]The tupistra chinensis extract has inhibitory effect on the platelets＇ aggregation and activation of rats colitis induced by TNBS.
出处
《中国中西医结合消化杂志》
CAS
2005年第6期363-365,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
湖北省卫生厅资助项目(2002JX1B013)
关键词
结肠炎
开口箭
血小板聚集率
P-选择素
colitis
tupistra chinensis bak
platelet aggregability
P-selectin
