摘要
目的:探讨熊去氧胆酸和多潘立酮片对胆汁反流性胃炎的疗效。方法:45例经胃镜检查证实的胆汁反流性胃炎患者随机分为三组,A组服用熊去氧胆酸(250mg,每日1次);B组服用多潘立酮片(10mg,每日3次);C组同时服用熊去氧胆酸和多潘立酮片。观察治疗后腹痛、腹胀、呕吐胆汁等症状变化情况,4周后复查胃镜。结果:治疗后三组患者症状均明显减轻(P<0.01),有效率分别为86.7%、93.3%和100%。症状平均消失时间为8.6d、7.9d和5.4d,C组与前两组比较有显著性差异(P<0.05)。胃内胆汁反流消失率分别为81.8%、84.6%和92.9%。结论:熊去氧胆酸联合多潘立酮片可减少胃内胆汁反流,能有效缓解胆汁反流性胃炎的症状。
Objective： To evaluate the effect of ursodeoxycholic （UDCA） and domperidone in bile-reflux gastritis. Methods：45 patients with bile-reflux gastritis proven by gastroscopy were divided into 3 groups equally at random, which were treated with UDCA 250 mg one day;domperidone 10 mg three times a day and both drugs respectively. The severity of the symptoms including abdominal pain,abdominal distention,nausea and bile vomitus were investigated before and four weeks after treatment. Gastroscopy was also reexamined. Results ：The .severity of the symptoms in the three groups decreased greatly after treatment（P〈0.01）. Average disappearance in a symptom were 8.6 days, 7. 9 days and 5.4 days. The difference in three groups was statistically significant （P〈0. 05）. The disappearance rate of intraastric bile-reflux in three groups were 81.8%, 84.6%和92.9%. Conclusion：UDCA combined domperidone can decrease the intragastric bile reflux,and are effective in bile reflux gastriris.
出处
《临床医药实践》
2005年第11期811-813,共3页
Proceeding of Clinical Medicine
