摘要
目的:探讨预防膀胱癌术后复发更有效的方法.方法:术中系统采用羟基喜树碱液行肿瘤基底及切缘注射,浸泡膀胱和切口,术后膀胱灌注羟基喜树碱液治疗154例膀胱癌患者.结果:随访6个月~5年,平均49.6个月,总复发率29.2%,1年复发率18.8%,2年复发率6.4%,3年复发率1.3%,4年复发率1.9%,5年复发率0.6%.无一例发生切口种植转移及严重并发症.结论:术中术后应用羟基喜树碱预防膀胱癌术后复发安全有效.
Objective:To investigate the more effective cure for the postoperative recurrence of bladder carcinoma. Methods: 154 patients were treated with tumor base injection, bladder incisional margin injection, bladder cavity and incision immersion intraoperatively, postoperation with the intravesical instillation of Hydroxycamptothecin (HCPT). Results: The follow-up survey was for 6 months-5 years,49. 6 months averagely. The total recurrence rate is 29.2%, and recurrence rate of 1-5 years is showed apart as 18.8%, 6.4%, 1.3%, 1.9%, and 0.6%. Neither incision margin metastasis, nor serious complication was found. Conclusions: The HCPT is safe and effective for preventing the postoperative recurrence of bladder carcinoma.
出处
《临床泌尿外科杂志》
2005年第12期757-759,共3页
Journal of Clinical Urology
关键词
膀胱肿瘤
药物治疗
羟基喜树碱
预防
Bladder carcinoma, Drug treatment
Hydroxycamptothecin
Prevention