摘要
目的探讨高血压患者左房到结构及功能变化与血浆心钠素水平的关系。方法应用超声心动图技术和放射性免疫测定法测定100例高血压患者的左房室结构及功能和血浆心钠素水平,并与50例年龄、性别配对的正常人比较。结果高血压左室肥厚组和非左室肥厚组血浆心钠素水平显著高于正常对照组(P<0.001),且左室肥厚组与非左室肥厚组之间亦有显著性差异;血浆心钠素水平与左房功能指标 LAV、LAT、LAP、LAF 及 MAP 呈高度线性意义,与 LAD、LVMI、LVEF、PFR、A峰、LVD、A/E 呈中度相关。结论随着高血压加重,血浆心钠素水平有增加趋势,测定血浆心钠素将有助于评价高血压左房室功能异常变化的程度。
Aim To explore the relationship be- tween plasm level of atrial natriuretic factor(PANF) and left atrial ventricular structure and function in patients with hypertension.Methods The PANF and left atrial ventricular structure and function were analyzed echocardiography and radioimmunoassay. Results The PANF of 100 hypertensive patients ei- ther with or without left ventricular hypertrophy was higher than those in control group(P<0.001).Sig- nificant PANF difference were found between with or without left ventricular hypertrophy in hypertensive group.PANF was found to be highly correlated to the atrial function indexes,such as left atrial volume (LAV),left atrial tension(LAT),left atrial pressure (LAP),left atrial ejection force(LAF)and mean ar- terial pressure(MAP),PANF was moderately corre- lated to left atrial diameters(LAD),left ventricular mass index(LVMI),left ventricular ejection fraction (LVEF),peak filling rate(PFR),peak velocity A, left ventricular diameters(LVD)and A/E ratio(P< 0.001).Conclusion The severity of hypertension was related to the PANF level,PANF was useful in estimating of pathologic degree of left atrial and ven- tricular hemodynamics in patients with hypertension.
出处
《高血压杂志》
CSCD
1996年第2期125-127,共3页
Chinese Journal of Hypertension
关键词
高血压
心功能
心钠素
超声心动图
hypertension
heart function
atrial natriuretic
echocardiography
