摘要
目的:观察复方甘草酸苷对慢性乙型肝炎患者肝功能和肝纤维化指标的影响。方法:33例慢性乙型肝炎患者静脉注射复方甘草酸苷注射液80ml,1次/d,连用4wk,观察治疗前、后肝功能、肝纤维化指标的变化和临床疗效。结果:轻度、中度、重度患者的总有效率分别为100%、92·3%、91·7%;治疗前、后比较,患者丙氨酸氨基转移酶、总胆红素有显著性差异(P<0·05),中度、重度患者的Ⅲ型前胶原、玻璃酸、层粘蛋白亦有显著性差异(P<0·05)。结论:复方甘草酸苷治疗慢性乙型肝炎疗效好,可明显改善其肝功能和肝纤维化指标。
OBJECTIVE： To study the effect of compound glycyrrhizin on hepatic function and hepatic fibrosis of patients with chronic hepatitis B. METHODS： 33 patients with chronic hepatitis B were injected i.v with 80ml compound glycyrrhizin q.d for 4 weeks. The hepatic function, hepatic fibrosis of patients and the clinic effects before and after treatment were observed. RESULTS： The total effective rates for patients with mild, moderate and severe degrees were 100% , 92.3% and 91.7%, respectively. There were significant differences in alanine aminotransferase, total bilirubin（P 〈 0.05） after treatment compared with that before. And significant differences were also noted in type Ⅲ precollagen, hyaluronic acid and laminin（P 〈 0.05）.CONCLUSON：Compound glycyrrhiz in has a significant curative effect on improving hepatic function and hepatic fibrosis in patients with chronic hepatitis B.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第23期1807-1808,共2页
China Pharmacy
关键词
复方甘草酸苷
慢性乙型肝炎
肝功能
肝纤维化
指标
Compound glycyrrhizin
Chronic hepatitis B
Hepatic function
Hepatic fibrosis
Index
