摘要
实验用３月龄雌ＳＤ大鼠，分基础对照组、年龄对照组、去卵巢组及去卵巢加尼尔雌醇治疗组（ＣＥＥ１ｍｇ·ｋｇ－１，每周ｉｇ１次），１２ｗ后，对各组大鼠胫骨近端不脱钙骨进行骨组织形态计量学分析。结果表明：去卵巢大鼠骨形成和骨吸收均明显增加，但骨吸收大于骨形成，出现高转换型骨质疏松。尼尔雌醇通过明显抑制去卵巢大鼠的骨吸收和骨形成，阻止骨高转换，保持骨量的正常。
SD rats (n=25) 3-month-old,female,were randomly divided into basal control,aging control,ovariectomized with either vehicle or nilestriol treatment group (1mg·kg-1,ig,once a week).After 12 week,all rats were killed.The proximal tibiae of rats were processed undecalcified sections of 20μm thickness for histomorphometric analysis,OVX reduced markedly the trabecular bone mass (-59%),due to bone turnover increase with bone resorption excessed bone formation,as compared with aging controls.In contrast,treatment of OVX rats with nilestriol resulted in normalization of trabecular bone volume and decreased histomorphometric indices of bone resorption and formation.The results indicate that nilestriol provide complete protection against osteoporosis in OVX rats.The protective mechanism involves nilestriol supression of bone turnover.Our findings would provide thooretic evidence for prevention and treatment of osteoporosis using nilestriol.
出处
《中国老年学杂志》
CAS
CSCD
1996年第4期227-229,共3页
Chinese Journal of Gerontology
基金
国家自然科学基金
关键词
尼尔雌醇
卵巢切除术
骨质疏松
Nilestriol
Overiectomy
Osteoporosis
Histomorphometry
