摘要
目的研究眼部分离细菌对4种氟喹诺酮类药物的敏感性。方法对525份眼部标本行体外细菌培养,K-B法观察培养阳性细菌对环丙沙星、氧氟沙星、左氧氟沙星和加替沙星的敏感性。结果体外培养阳性细菌321株,革兰阳性球菌最多,为245株(76.3%),其次,革兰阴性杆菌48株(15.0%),革兰阳性杆菌20株(6.2%),革兰阴性球菌8株(2.5%),环丙沙星、氧氟沙星、左氧氟沙星和加替沙星的总敏感性分别为59.2%、66.4%、80.7%和96.6%。环丙沙星、氧氟沙星对表皮葡萄球菌的敏感性(47.6%,55.3%)明显低于左氧氟沙星和加替沙星(76.0%和97.1%)(P<0.05)。结论眼部分离细菌以表皮葡萄球菌最多,其次为金黄色葡萄球菌。加替沙星的敏感性最好,其次是左氧氟沙星。
Objective To assess the sensitivity of four fluoroquinolone to ocular isolating bacteria in vitro. Methods 525 samples of ocular bacteria from Henan Institute of Ophthalmology were isolated from October,2003 to Febeuary ,2005 to determine their susceptibility to ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin in vitro by the Kirby-Bauer disk diffusion method. Results 321 strains of bacteria were isolated from conjunctival sac,cornea,anterior chamber and vitreous in 525 samples,including gram-positive cocci 245 （76. 3% ） , gram-negative cocci 8 （ 2.5% ）, gram-positive bacilli 20 （ 6. 2% ） and gram-negative bacilli 48 （ 15.0% ）. The percentage of susceptibility in total ocular isolates to ciprofloxacin,ofloxacin,levofloxacin,gatifloxacin was 59. 2% ,66. 4% ,80. 7% and 96. 6% respectively. The susceptibility of steaphylococcus epidermidis to ciprofloxacin （ 47.6% ） and ofloxaein （ 55.3% ） was lower significantly than levofloxacin（76. 0% ） and gatifloxacin （97. 1% ） （P 〈 0. 05 ）. The total sensitivity of gatifloxacin to ocular bacterial isolates was significantly higher than that of other three drugs （ 96. 6% versus 59. 2% , 66. 4% and 80. 7% , P 〈 0. 05 ）, and that of levofloxacin was higher than ciprofloxacin,ofloxacin （80. 7% versus 59. 2% and 66. 4% ,P 〈 0. 05 ）. Conclusion The major bacteria isolated from eye is steaphylococcus epidermidis and then follows steaphylococcus aureus. Gatifloxacin is the most sensitive drug to the all of ocular bacterial isolates in the four drugs tested ,and the second one is levofloxacin.
出处
《眼科研究》
CSCD
北大核心
2005年第6期610-612,共3页
Chinese Ophthalmic Research
关键词
氟喹诺酮
体外药敏试验
眼部分离细菌
fluoroquinolone
antimicrobial sensitivity test
ocular bacterial isolates
