摘要
溶脲脲原体（Ｕ．Ｕ．）是泌尿生殖道常见的病原体。在Ｕ．Ｕ．上行性感染的动物模型中，已证明睾丸可发生明显的病理损伤。本文以对数生长期Ｕ．Ｕ．及热灭活Ｕ．Ｕ．加入培养的小鼠Ｔ淋巴细胞中，并检测Ｔ淋巴细胞产生ＩＦＮ－ｒ的活性。实验表明低剂量活Ｕ．Ｕ．与热灭活Ｕ．Ｕ．可使Ｔ产生ＩＦＮ－ｒ的活性明显高于对照组（Ｐ＜０．０５）。而高剂量活Ｕ．Ｕ．可抑制Ｔ产生ＩＦＮ－ｒ（Ｐ＜０．００５）。提示Ｕ．Ｕ．
U.U. is one of the common existed pathogens in the urogenital tracts. It has been verified that Ureaplasma Urealyticum (U.U). infection could lead to significant pathologic changes in testis using an animal model of asending U.U. infection. In this paper, we reported the effect of U.U. on IFN r production by mouse T lymphocyte. It has been show that both lower amount of living U.U. at loganithmic growth phase and the heat inactivated U.U. can stimulate the production of IFN r by the mouse T cell (P<0.05) and relative higher amount of living U.U. can inhibit the production of IFN r (P<0.05). It has been suggested that the microenvironment changes one of which is the IFN r increase or decrease, might be closely related to the pathologic changes in testis of U.U. infectious animal model.
