摘要
用增殖细胞核抗原（PCNA）免疫组织化学方法对65例食管瘤进行了观察，结果发现：食管瘤的PCNA表达与分化程度（P＜0．01）、浸润深度（P＜0．05）和淋巴结转移（P＜0.01）关系密切．PCNA阳性细胞的平均计数为：分化Ⅰ级254±3．2，分化Ⅱ级40．3±4．5，分化Ⅲ级684±6．2；淋巴结阳性组52．6±6．4．阴性组29．4±3．3,提示：PCNA的表达对食管癌的组织学分级及估价预后是一项有效的指标。
Proliferating cell nuclear antigen(PCNA) immuno-histochernistry had been determined in 65 cases of esophageal carcino-ma. The results show that there is a close relationship between the PCNA experssion with degree of differentiation (P<0. 01 ) .depth ofifiltration (P<0.05 ) and lymphnode metastasis (P<0.01). The mean count PCNA positive cell ln grade was 25. 4 ± 3. 2. gre Ⅱ40. 3±4. 5,grade Ⅲ 68. 4± 6. 2; and that in lymphnode Positive group was 52. 6 ± 6. 4. negative grouP 29. 4 ± 3. 3. It is dernonstratedthat PCNA expression is a usefuI index for histlogical grade of esophgeal carcinorna and prognostic evaluation.
