摘要
目的探索呼吸道合胞病毒(RSV)肺炎患儿细胞免疫状况的变化。方法采用流式细胞仪检测RSV肺炎急性期患儿及正常对照组外周血T辅助淋巴细胞1(Th1)和T辅助淋巴细胞2(Th2)的百分率、CD4+细胞百分率、CD3、CD8、NK细胞、B细胞百分率及CD4/CD8比值。结果RSV肺炎急性期患儿的外周血Th1、Th2的细胞百分率〔(11.96±6.26)%、(3.45±2.03)%〕均显著高于对照组〔(9.16±9.90)%、(2.14±1.12)%〕,(P<0.05);但RSV肺炎组Th1/Th2之比值、CD3、CD8、NK细胞、B细胞百分率及CD4/CD8比值,均与正常对照组之间无统计学差异(P>0.05)。结论RSV感染可活化T辅助淋巴细胞亚群,表现为Th1和Th2细胞百分率均增加,Th1和Th2细胞免疫反应增强。
Objective To investigate the alteration of cellular immunity in the respiratory syncytial virus （RSV） pneumonia. Methods Detecting the expression of T assistant lymphocyte subsets in peripheral blood of young children with RSV pneumonia in comparison with normal children using flow cytometer, including the percentage of Thl, Th2, CD4^＋ cells, NK cell, B cell, CD3, CD8 cells, and the ratio of CD4/CD8. Results The percentage of Thl and Th2 [（11.96 ± 6.26） % ,（3.45 ± 2.03）% ] were significantly greater compared to normal children [（9.16±9.90）%, （2.14±1.12）%] ,P〈0.05. There was no difference between RSV pneumonia comparison and normal children in the ratio of Th1/Th2,CD3,CD8 cells, percentage of Nk cell, B cell and the ratio of CD4/ CD8. （P〉0.05）. Conclusion T assistant lymphocyte subsets can be activated by RSV infection, displaying the increase of the percentage of Th1 and Th2. The cellular immunity reaction of Th1 and Th2 enhances.
出处
《重庆医学》
CAS
CSCD
2005年第12期1818-1819,1822,共3页
Chongqing medicine
