摘要
目的观察纳络酮佐治新生儿窒息的实际临床价值.方法对2000～2004年我院89例存活的重度窒息的新生儿患者进行回顾性分析,按是否使用纳络酮分为两组.42例为纳络酮治疗组,未使用纳络酮的47例为对照组.两组除按相同窒息复苏程序与常规综合治疗外,治疗组辅以纳络酮治疗.观察患儿脑损伤的临床症状表现变化及新生儿行为神经评分测定(NB-NA)评分.结果两组新生儿缺氧缺血性脑病(NHIE)临床症状表现及NBNA评分的差异无显著性(P＞0.05).结论纳络酮不能加速NHIE后临床症状的缓解,对远期预后的改善可能无效.在新生儿窒息复苏治疗原则中,综合治疗更为重要,而纳络酮的实际应用价值还需进一步研究.
Objeetive To observe the actual clinical value of naloxone used as an add-on therapy in treating newborns with asphyxia. Methods Eighty-nine surviving newborns with severe asphyxia, selected from 2000 to 2004, were retrospectively analyzed. All cases were divided into the treating group（42 patients） and the control group（47 patients）, The same processes of resuscitation and integrated treatments were used in both groups, while the treating group was additionally treated with naloxone. The clinical symptoms of brain damage were observed and NBNA scores were performed. Results The symptoms and NBNA score of newborns with HIE had no significant statistical difference（P〉0.05） between two groups after treatment. Conclusion Naloxone could not effectively accelerate to alleviate clinical symptoms, then might have no value on long-term prognosis, so integrated therapy would be more important in therapy principles of asphyxia resuscitation. Naloxone＇s actual value should be further researched.
出处
《重庆医学》
CAS
CSCD
2005年第12期1853-1853,1855,共2页
Chongqing medicine
关键词
新生儿
窒息
复苏
纳络酮
newborn
asphyxia
resuscitation
naloxone
