摘要
用磺酸酯法制备单端氨基聚乙二醇引发剂,引发谷氨酸苄酯羧酸酐开环聚合,生成可生物降解的两亲嵌段共聚物聚乙二醇﹣聚谷氨酸苄酯(PEG-PBLG),用IR,NMR和GPC表征了共聚物。用超微透析法制备PEG-PBLG聚合物纳米粒,荧光芘探针法测定纳米粒的临界聚集浓度(cac)。紫外分光光度计考察纳米粒对疏水性药物的增溶作用,PEG-PBLG可作为亚微粒药物输送系统的载体。
The biodegradable block copolymer poly （ethylene glycol）-poly（γ-benzyle-L-glutamate） （PEG-PBLG） was synthesized by polymerization of γ-benzyle-L-glutamate-N-carboxyanhydride initiated with MePEG; Their structure and molecular weight were characterized by IR, NMR and GPC. The PEG-PBLG nanoparticles were prepared by diafiltration method. Solubilization was investigated by UV spectrophotometer; the critical aggregation concentration （cac） obtained by fluorescence spectroscopy.
出处
《广州化学》
CAS
2005年第4期9-16,共8页
Guangzhou Chemistry
关键词
聚乙二醇-聚谷氨酸苄酯
纳米粒
临界聚集浓度
poly（ethylene glycol）-poly（γ-benzyle-L-glutamate）, nanoparticles, critical aggregation concentration
