摘要
应用免疫组织化学方法对36例喉鳞癌患者的nm23基因产物/核苷二磷酸激酶(nm23/NDPK)进行检测。结果:喉鳞癌中nm23/NDPK表达的阳性率为69.4%(25/36);随着肿瘤的增大及淋巴结转移的出现,nm23表达程度降低,T1-2病变高于T3-4病变;Ⅰ~Ⅱ期喉癌高于Ⅲ~Ⅳ期喉癌;无颈淋巴结转移者高于颈淋巴结转移者(P<0.05)。nm23/NDPK表达与肿瘤生长部位及病理分级无关。表明nm23基因低表达可能是肿瘤进展和颈淋巴结转移的相关因素。
Using immunohistochemical technique to detect the expression of antimetastatic gene in laryngeal squamous cell carcinoma in 36 cases. Of these 25(69.4%)cases showed immunoreactivity in nm23/NDPK. Statistical analysis revealed that the decreases in expresion of nm23/NDPK was significantly correlated with cervical lymph node metastasis and with advanced stages of laryngeal carcinoma( P <0. 05), No relationship was found among nm23/NDPK expression,histopathological grades and tumor sites. The results suggest that nm23 gene may play a role in the mechanism of tumor progression and the development of regional metastasis from these tumors.
出处
《临床耳鼻咽喉科杂志》
CSCD
1996年第5期259-261,共3页
Journal of Clinical Otorhinolaryngology