摘要
在家兔桡骨中段造成１５ｍｍ骨缺损，分别植入骨形态形成蛋白和纤维蛋白粘合剂及二者复合物，并设空白对照。术后第二、四、八周分别行Ｘ线及核素骨显像检查，发现复合物和骨形态形成蛋白组缺损均骨性愈合，纤维蛋白粘合剂和空白组则形成骨不连，两周时含Ｆ５组缺损区血流量大于其它组。定量分析表明，复合物组缺损区新骨量大于骨形态形成蛋白组（Ｐ＜０．０５），说明ＦＳ与ＢＭＰ复合后可增强ＢＭＰ修复骨缺损的能力，骨显像检查可定量观察修复过程中缺损区血流量及成骨活动。
15mm-segment of osteoperiosteal bone was excited from the both radius of rabbit.Composite ofbone norphogenetic protein with fibrin sealant(BMP/FS)or either of the two was implanted in the defectedarea.X-ray examination performed on the 14th.28th and 56th post-operation days revealed that all thedefects treated with BMP/FS and BMP had bridged and those treated with FS or none had developed intonon-union.On the same deys,bone scanningraphy with 99m Tc-MDP showed that,there was a generl-ized increase in tracer uptake in the operated limbs with a localized concentration in the defected area.Quan-titative evaluations indicated that there was a significant increase in new bone formation in BMP/FS groupsas compared with BMP groups.
出处
《兰州医学院学报》
1996年第2期14-17,共4页
Journal of Lanzhou Medical College
