摘要
目的验证激光与组织光热效应预示模型和计算结果,考查激光功率密度和照射时间与组织温度和损伤的定量关系,获得组织热效应的温度数据。方法连续Nd∶YAG激光照射活体皮肤组织,组织为全身麻醉状态下大鼠腹部皮肤,每次实验同时测量三路信号:表面照射点辐射温度、皮下1mm的内部温度和环境温度。为了获得不同条件下的温度数据,根据照射功率和时间进行分组。结果得到连续Nd∶YAG激光相同照射时间(t=1s)时不同功率(P=2、3、4、5W)、相同功率(P=5W)时不同照射时间(t=0·5、0·8、1·0s)以及照射功率较高时(t=0·5s,P=5、10、15W)的大鼠皮肤组织皮下1mm的温度。温度随着功率和照射时间的增加相应升高,温度响应形状相似,温度上升时间与照射时间相关。结论Nd∶YAG激光表面辐射温度远远低于皮下温度,对热效应研究意义不大。热电偶所测内部温度能够很好地反映激光功率、照射时间的变化,可用来验证相关模型和数值模拟结果。
Objective In order to verify the prediction model and computation results of laser and tissue photo-thermal effects, to find out the quantification relation between laser fluence rate and irradiation time with the tissue temperature and thermal damage, and to acquire the temperature data of tissue. Methods The skin tissue of rat abdomen under anesthesia was irradiated by continuous Nd ： YAG laser in vivo, and the real time temperature was measured. Every time three signals were measured simultaneously, including the irradiation temperature of surface irradiated point, the inner temperature of about lmm right under the irradiated point and the environment temperature. To gain temperature data under different conditions, the experiments were grouped by irradiation power and time. Results The inner temperature of about 1 mm right under the irradiated point of rat skin tissue was measured, with three different conditions of application continuous Nd ： YAG laser, i. e. , the same irradiation time （ t = 1 s ） and different power （ P = 2,3,4,5 W） ; the same power （P = 5 W ） and the different irradiation time （ t = 0. 5,0. 8,1.0 s ）, and higher irradiation power （ t = 0. 5 s, P = 5,10,15 W）. The results showed the temperature increased with irradiation power and time, the temperature response shape was similar and the temperature rise time was correlated with the irradiation time. Conclusions The surface radiation temperatures are much lower than the inner temperature after Nd ： YAG laser irradiation, which maybe of less research worth in thermal effect. The inner temperature can reflect the change with laser power and irradiation time, and can be used to verify related model and numerical simulation results.
出处
《中国激光医学杂志》
CAS
CSCD
2005年第6期350-353,共4页
Chinese Journal of Laser Medicine & Surgery
关键词
激光
活体组织
测温
热电偶
Lasers
In vivo tissue
Temperature measurement
Thermocouple
