摘要
目的探讨谷氨酰胺对大鼠实验性急性肝功能不全的防治作用。方法腹腔注射D-氨基半乳糖(GalN)建立急性肝功能不全大鼠模型,并测定血清生化指标和肝组织病理检查。结果肝功能检测显示:造模后24,48h肝脏损伤程度,与模型组相比,防治组的肝损较轻(P<0.05)。肝脏病理切片结果:防治组的损伤程度明显轻于模型组,两者差异显著(P<0.05)。结论谷氨酰胺对GalN致急性肝功能不全大鼠有明显的保护作用。
OBJECTIVE The present experiments were designed to study the protective effects of glutamine on rats with acute hepatic failure. METHODS Establishing the acute hepatic failure models by intraperitoneal injection of galatosamine. Biochemical indexes and histopathological examination were determined. RESULTS At 24 hours,48 hours after intraperitoneal injection of gala- tosamine, biochemical indexes（ ALT, AST,TBIL） level in the glu-treated group were significantly lower than those of the model group （P 〈 0.05 ）. Histopathological examinations indicated that the glu-treated group had much slighter lesion compared with the model group（ P 〈 0.05）. CONCLUSION The present results showed that glutamine can effectively lighten galatosamine-induced liver necrosis.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2005年第6期508-510,共3页
Chinese Journal of Modern Applied Pharmacy
