摘要
目的探讨老年高血压患者中冠心病、脑卒中、糖尿病、高脂血症等因素与认知功能和日常生活质量的相关性.方法常规体检中随机抽查60～93岁老年人542名[平均年龄(73.6±6.8)岁],其中男性:494例;女性:48例,检测血压、血糖和血脂,同时进行简易精神状况量表(MMSE)和日常生活能力(ADL)的测试,将所得结果用SAS6.12版统计软件分析.结果结果显示高血压组321例(59.2%),非高血压组221例(40.8%).高血压组中合并冠心病125例(38.9%)、合并脑中风60例(18.7%)、合并高脂血症193例(60.1%)、合并糖尿病88例(27.4%)、联合合并高脂血症与糖尿病58例(18.1%),以合并冠心病、脑卒中、糖尿病较非高血压组明显增多(P<0.01).高血压组ADL成绩(23.3±7.9)明显高于非高血压组(21.6±4.7)(P<0.05),两组MMSE评分无差异.高血压按是否合并糖尿病、高脂血症分组后进行认知功能评分,高血压并存高脂血症组MMSE成绩(28.4±1.6)最高,高血压并存糖尿病组MMSE成绩(25.3±2.7)(P<0.01)、高血压同时合并糖尿病、高脂血症组MMSE成绩(27.0±2.5)明显降低(P<0.05),但以单纯合并糖尿病组下降最显著.结论用MMSE法评估老年高血压与非高血压组发现两组认知功能状况无显著差异.日常生活能力降低,可能与高血压者心、脑血管意外事件并发率高有关.老年高血压并存糖尿病认知功能明显降低,提示糖尿病是影响认知功能的独立危险因素.并存高脂血症者降脂治疗对认知功能有改善.
Objective To evaluate the impact of hypertension related diseases, such as coronary artery disease（CAD）, cerebral apoplexy, diabetes, hyperlipemia on cognitive function and daily life quality in elderly people with hypertension. Methods Five hundred forty-two individuals from routine health examination（male 494, female 48, average age 73.64 years, aged 60 to 93 years）, were interviewed and examined for blood pressure, plasma glucose and blood-fat. The cognitive abilities and mental status were evalued using MMSE and ADL. Results Hypertension were diagnosed in 321 subjects（59.2% ）. 125 （38.9%） were accompanied with CAD, 60 （ 18.7% ） with cerebral apoplexy, 193 （ 60.1% ） with hyperlipemia, 88（27.4% ）with diabetes, and 58（18. 1%） with hyperlipemia and diabetes. Hypertension group had a higher ADL score（23.3±7.9） than that of subjects without hypertension （21.6±4.7, P〈0.05）. The MMSE score was of no difference between two groups. Patients with hypertension accompanied with hyperlipemia had higher MMSE score（28.4±1.6） than hypertension alone （P〈0.05）, while the lowest MMSE score was found in the hypertensive patients complicated with diabetes （25.3± 2.7） （P〈0. 01）. Conclusion There is no difference in cognitive function between aged people with and without hyperten- sion, however, the fact that quality of life in hypertension group is worse than that of without hypertension may be attributed to the higher incidence of cardiac-cerebral vascular accidents. Patients who have both hypertension and diabetes tend to be more likely to develop cognitive impairments.
出处
《高血压杂志》
CSCD
北大核心
2005年第12期779-782,共4页
Chinese Journal of Hypertension
基金
上海市科委科研基金资助。项目编号:00HX016
关键词
高血压
糖尿病
高脂血症
认知功能
日常生活能力
Hypertension
Diabetes
Hyperlipidemia
Cognitive function
Daily life quality
