生长激素缺乏儿童血清胰岛素样生长因子-1和瘦素水平的变化及其相互关系被引量：4

Changes and Relationship of Serum Insulin-Like Growth Factor-1 and Leptin in Children with Growth Hormone Deficiency

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摘要目的探讨生长激素缺乏(GHD)儿童血清胰岛素样生长因子1(IGF1)、瘦素水平的变化。方法用放射免疫法分别检测20例正常青春期前儿童和23例GHD患儿血清IGF1和瘦素的水平。结果GHD组血清IGF1水平(51.158±29.988)μg/L低于对照组(112.680±41.540)μg/L,两者有显著差异(t=5.619P<0.01);瘦素水平(6.002±2.204)μg/L高于对照组(4.523±2.204)μg/L,两者比较有显著差异(t=2.225P<0.05);但IGF1和瘦素之间无相关性(P>0.05)。结论IGF1和瘦素对GHD患儿生长发育的调节作用是相互独立的。 Objective To explore the changes and relationship of serum insulin - like growth factor - 1 （ IGF - 1 ） and leptin in children with growth homlone deficiency（GHD）. Method Serum 1GF- 1 and leptin levels were measured by immunoradiometric assay in 20 prepuberal normal children and 23 children with GHD. Results Serum IGF- 1 level in GHr） group（ 51.158 -＋ 29. 988）μg/L was significantly lower than that in controls（ 112. 680 ± 41. 540）μg/L. Serum leptin levels in GHD group（6. 002 ± 2. 204）μg/g was significantly higher than that in commls（4. 523± 2. 204）μg/g. There was no significant correlation between serum IGF- 1 and leptin. Conclusion IGF- 1 and leptin regulate growth in children with GHD in their individual way.

作者张晓莉董俊华

机构地区山东大学齐鲁医院儿科

出处《实用儿科临床杂志》 CAS CSCD 北大核心 2005年第12期1198-1199,共2页 Journal of Applied Clinical Pediatrics

关键词生长激素胰岛素样生长因子1 瘦素 growth homxme deficiency insulin - like growth factor- 1 leptin

分类号 R725.8 [医药卫生—儿科]

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