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Caspase-3在大鼠中枢神经系统的表达研究

Study on the expression of caspase-3 in central nervous system of rat
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摘要 目的研究caspase-3在大鼠中枢神经系统的表达及其意义。方法用western-blot方法对出生1天和3个月SD大鼠的大脑皮质、中脑和小脑组织的caspase-3进行半定量测定。结果出生1天大鼠脑的caspase-3表达较高,出生3个月大鼠脑的caspase-3表达较低。结论caspase-3在中枢神经系统的发育成熟过程中对神经元的凋亡起着关键性作用。 Objective To study the expression of caspase-3 in central nervous system of rat. Method Western-blot was used to study the expression of caspase-3 in the cerebral cortex, midbrain and cerebellum of rats about one day and three months old. Results Caspase-3 was expressed higher in the brain of rat about one day than that of three months old. Conclusion Caspase-3 played an important role in neuronal apoptosis during development and growth of central nervous system.
作者 陈雪梅 杜显刚 官鹏 谭志巍 王亚琴
机构地区 四川大学华西基础医学与法医学院
出处 《四川解剖学杂志》 2005年第4期5-7,共3页 Sichuan Journal of Anatomy
基金 本课题受国家自然科学基金资助(基金编号30470660) 四川大学科技创新基金资助(基金编号2004CF08)
关键词 半胱氨酸天冬氨酸蛋白酶-3 脑 细胞凋亡 WESTERN印迹法 大鼠 中枢神经系统 Caspase-3 Brain Apoptosis Western-blot
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献10

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四川解剖学杂志
2005年 第4期

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