摘要
目的:探讨分娩期产妇焦虑状态与血液中3-0-甲基肾上腺素、去甲肾上腺素、催产素、催乳素水平的变化及其意义。方法:随机选择2003年1至5月成功阴道分娩、孕足月、单胎、无产科合并症,既往无精神病史产妇52例,根据HAD量表分成焦虑组(22例)和无焦虑组(30例),宫口开全时抽产妇静脉血应用酶联免疫法和放射免疫法检测血液3-0-甲基肾上腺素、去甲肾上腺素、催产素、催乳素水平。结果:焦虑组产妇血液中3-0-甲基肾上腺素及去甲肾上腺素明显高于无焦虑组(P<0.001),而血液中催产素及催乳素水平明显低于无焦虑组(P<0.001);产妇焦虑评分与血液中3-0-甲基肾上腺素及去甲肾上腺素呈正相关(P<0.001),与血液中催产素及催乳素呈负相关(P<0.001);焦虑组产妇产后出血率及胎儿窘迫发生率较对照组明显增高(P<0.05)。结论:4种激素水平的改变,可以为分娩期产妇焦虑提供神经生化方面病因学的基础,积极防治产妇焦虑,可以降低因为产妇情绪异常而产生的产科不良并发症,提高产科质量。
Objective： To study the significance of plasma neuroendocrine hormones such as metanephrine, norepinephrine, oxytocin and prolactin in puerperants with anxiety. Methods： 52 puerperants who were vaginal birth, pregnant time ≥ 37weeks, primipara, non-obstetrics complication, non-mental disease history were selected randomly from obstetrics of Hainan Provincial Peopleg Hospital from January to May ,2003. They were divided into anxiety group （22 cases） and control group（30 cases） based on Hospital Anxiety and Depression. The blood samples of 52 puerperants＇were taken from the intravenous immediately and determined for metanephrine,noradrenaline, oxytocin and prolactin when the cervix was dilated 10cm. Results： The concentrations of metanephrine and noradrenaline in the blood of anxiety group were significantly higher than those of the control group（P 〈 0. 001 ）. The concentrations of oxytocin and prolactin in the blood of anxiety group were significantly lower than those of the control group（ P 〈 0. 001 ） ;There was a significant positive correlation between the degree of puerperants＇anxiety which were selected randomly and the concentrations of metanephrine, noradre-naline in the puerpera＇s blood（P 〈 0. 001 ）. On the other hand, there was a significant negative correlation between the degree of puperperas＇ anxiety and the plasnla concentrations of oxytocin, procactin （ P 〈 0. 001 ）. The inciddence rates of postpartum hemorrhage and fetal distress in anxiety group were higher than those of control group（ P 〈 0.05 ）. Conclusion：To study the changes of four kinds of ncuroendocrine hormones can provid some pathogensis basis for puerperants with psychologic abnormality during the labour. To prevent and treat the anxiety of puerpera can de- crease the harmful complication owing to feeling disorder and improve the quality of obstetrics.
出处
《现代妇产科进展》
CSCD
北大核心
2005年第6期480-482,共3页
Progress in Obstetrics and Gynecology
