摘要
70年代中期,β-内酰胺类抗生素的研究取得了突飞猛进的发展,在对基本青霉素母核及头孢母核的改造中获得巨大成功,合成了青霉素母核(Ia)、碳青霉烯母核(olivanic acid)、砜类青霉素母核(II)及单环β-内酰胺等。把头孢菌素母核改造为具有抗菌活性的氧头孢菌素(IIIa)及碳头孢菌素(IIIb),但改造后的异氧头孢(IV)、头孢烷酸(V)及δ3头孢菌素的生物活性都非常低。本文综述近年来报道的对β-内酰胺类化合物母核改造的研究及其多样的生物活性。
Until the middle of the 1970＇ virtually all the significant developments in β-lactam antibiotics had been achieved. Penems were synthesized, naturally occurring carbapenems, oxapenams and monocyclicβ-lactams were discovered. The cephalosporin nucleus was modified to produce microbiologically active oxacephems and carbacephems, however, oxocephems, cephams andδ3-cephem has little or no activity. The purpose of this review is to draw attention to, further chemical modification with some surprising biological results.
出处
《天津药学》
2005年第6期45-48,共4页
Tianjin Pharmacy
