摘要
通过对２７例小儿狼疮肾炎的病例分析，发现狼疮肾炎是系统性红斑狼疮患儿较早出现的脏器损害，多数在起病后一年内发生，同时伴有肾内外多样化表现。其中临床分型为肾病综合征型占７４％，提示此型为小儿狼疮肾炎的好发类型，该型对四种不同治疗效果均较其它型为差。目前临床提倡早期规则给予环磷酰胺冲击治疗，以防止肾纤维化，抑制其活动性。
Twenty seven ospitalized children patients with childhood lupus nephritis between 19 92 and 1 9 94 were analyzed clinically, THe result showed that renal involvement is the most common organ injury which occurred within one year after onset in most cases associated with renal and extra-renal multi-system manifestations。 Twenty cases(74%)presenting nephrotic syndrome pattem were less responsible to four different kinds of treatment. It is necessary to early introduce pulse treatment with cyclophospamide(cytoxan)introvenously per month with a dose of 0. 8-1g/m2 for those tho had active disease and unresponsible to corticosteroid therapy alone to prevent renal fibrosis.
出处
《北京医学》
CAS
北大核心
1996年第4期199-201,共3页
Beijing Medical Journal
关键词
狼疮性肾炎
环磷酰胺
儿童
Systemic lupus erythematosus
Lupus nephritis
Cyclephosphamide(cytoxan
CTX)
