期刊文献+

米多君预防反复发生的血液透析相关性低血压疗效观察 被引量:12

The effects of Midodrine treatment in patients with hemodialysis-related hypotension
下载PDF
导出
摘要 目的观察米多君预防反复发生的血液透析相关性低血压(IDH)的效果。方法广州中山大学附属第一医院肾内科反复发生IDH的血液透析患者27例,口服米多君2.5~5.0mg/次,每天3次,血液透析前或既往IDH出现前30min再服米多君5mg,透析处方不变,观察透析中血压变化和IDH发生情况。结果27例血液透析患者米多君治疗前后血液透析中脱水速度、透析液钠浓度和温度、透析前血压比较差异没有显著性(P>0.05);米多君治疗后总脱水量、Kt/V、透析结束血压均高于治疗前(P<0.05),透析过程最低血压与透析前血压的差值低于治疗前(P<0.01),IDH发生例次、症状性IDH发生例次均低于治疗前(P<0.01),其中显效11例(40.73%),有效9例(33.3%),无效7例(占26.0%)。结论米多君可有效预防IDH的发生。 Objective To study the effect of midodrine to prevent the hemodialysisrelated hypotension (IDH) in maintained-hemodialysis (MHD) patients. Methods 27 MHD patients who had usually showed IDH were involved. These patients received hemodialysis with the same hemodialysis prescription, but took orally Midodrine 7.5~15mg for three times every day, and took orally another 5mg at 30 minutes before hemodialysis or onset of IDH. Blood pressure and IDH were observed during hemodialysis. Results Ultrafiltration rate, pre-hemodialysis blood pressure, temperature and sodium concentration of dialysate were no significant difference between before and after Midodrine treatment in 27 cases (P 〉 0.05).. After Midodrine treatment, total ultrafiltrated volumes, the lowest intrahemodialysis blood pressure, and post-hemodialysis blood pressure were increased significantly (P〈0.05), and the cases showed IDH, symptomatic IDH were reduced(P〈0.01). Midodrine treatment showed significant effect in ii cases (40.7%), showed effect in 9 (33.3%), and showed no effect in 7 (26.0%). Condusion We suggest that Midodrine treatment can effectively prevent hemodialysis-related hypotension in MHD patients.
出处 《中国血液净化》 2005年第12期657-659,共3页 Chinese Journal of Blood Purification
关键词 慢性肾衰竭 盐酸米多君 血液透析 低血压 Chronic renal failure Midodrine Hemodialysis Hypotension
  • 相关文献

参考文献10

  • 1Perazella MA. Pharmacologic options available to treat symptomatic intradialytic hypotension. Am J Kidney Dis,2001, 38(4 Suppl 4): S26-S36.
  • 2周福德,蔡红梅,王梅.血液透析患者血容量监测的意义[J].肾脏病与透析肾移植杂志,2001,10(6):528-531. 被引量:42
  • 3Perazella MA. Midodrine: a new therapy for intradialytic hypotension. Sem Dial, 1997, 10:245-247.
  • 4秦晓新,关煜,王质刚.治疗血液透析相关低血压的新对策[J].中国医刊,2001,36(8):24-26. 被引量:27
  • 5Montagnac R, Clavel P, Delhotal-Landes B, et al. Use of midodrine (Gutron) to treat permanent hypotension in a chronic hemodialysis patient. Clin Nephrol, 2001, 56(2):162-168.
  • 6Flynn JJ, Mitchell MC, Caruso FS, et al. Midodrine treatment for patients with hemodialysis hypotension. ClinNephrol, 1996, 45(4): 261-267.
  • 7Blowey DL, Balfe JW, Gupta I, et al. Midodrine efficacy and pharmacokinetics in a patient with recurrent intradialytic hypotension. Am J Kidney Dis, 1996, 28(1):132-136.
  • 8Cruz DN, Mahnensmith RL, Brickel HM, et al. Midodrine is effective and Safe therapy for intradiaoytic hypotension over 8 months of follow-up. Clin Nephrol, 1998, 50(2):101-107.
  • 9Chang MH, Chou KJ. The role of autonomic neuropathy in the genesis of intradialytic hypotension. Am J Nephrol, 2001,21(5): 357-361.
  • 10唐知还,姚建,黄朝瑾,徐琴君.血液透析患者自主神经损害与透析中心律失常及低血压的关系[J].肾脏病与透析肾移植杂志,2001,10(3):248-250. 被引量:10

二级参考文献12

  • 1[1]Ewing DJ,Clarke BJ.Diagnosis and management of diabetic autonomic neuropathy.BMJ,1982,285:916
  • 2[2]Daugirdas JT,Ing TS.Handbook of Dialysis.First Edition:Boston,Massachusetts:Little,Brown and Company,1988.479
  • 3[3]Jassal SV,Coulshed SJ,Douglas JF et al.Autonomic neuropathy predisposing to arrhymias in hemodialysis patients,Am J Kidney Dis,1997,30(2):219
  • 4[4]Takahashi H,Matsuo S,Toriyama T et al.Autonomic dysfuction in hemodialysis patients with persistent hypotention.Nephron,1996,72(3):418
  • 5[5]Agarwal A,Anand IS,Sakhuja V et al.Effect of dialysis and renal transplantation on autonomic dysfunction in chronic renal failure.Kidney Int,1991,40:489
  • 6[6]Collins J,Massry SG,Campese VM et al.Parathyroid hormone and the altered vascular response to norepinephrine in uraemia.Am J Nephrol,1985,5:110
  • 7[1]Sherman RA. The pathophysiologic basis for hemodialysis - related hypotension. Sem Dial,1988,1:136 - 142
  • 8[2]Paik - seong Lim. Midodrine for the treatment of intradialytic hypotension. Nephron, 1997,77: 279 - 283
  • 9[3]Fouad - Tarazi FM, et al. Alpha - sympathomimetic treatmeat of autonomic insufficiency with orthostatic hypotension. Am J Med, 1995,99:604 - 610
  • 10[4]Flynn JJ,et al. Midodrine treatment for patients with hemodialysis hypotension. Clin Nephrol, 1996,45: 261 - 267

共引文献72

同被引文献74

引证文献12

二级引证文献56

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部