摘要
目的:探讨肝脏病变时IgA和sIgA对临床诊断的意义.方法:肝病患者共168例,包括急性肝炎35例,慢性重症肝炎9例,慢性肝炎67例,肝硬化57例,用免疫速率比浊法检测IgA,用放射免疫分析法检测sIgA.结果:肝脏患者粪便IgA,sIgA均显著高于正常对照组(IgA:100±47,251±178,80±24,145±164mg/Lvs<67mg/L,P<0.01;sIgA:88±96,326±237,88±121,104±109mg/Lvs13±10mg/L,P<0.01),IgA和sIgA呈显著正相关(r=0.4371,P<0.01).血清中IgA和sIgA显著高于正常对照组(IgA:3.1±1.1,3.4±1.8,3.3±1.7,4.9±3.3g/Lvs1.6±0.2g/L,P<0.01;sIgA:31.1±25.8,80.3±25.4,30.5±24.1,50.0±20.5g/Lvs23.4±8.2g/L,P<0.01或P<0.05),便IgA和sIgA与血清中IgA,sIgA含量无相关性,血清中IgA与血清中sIgA亦无相关性.慢性肝炎、慢性重症肝炎、肝硬化患者血清sIgA与碱性磷酸酶(r=0.5230,P<0.01)、总胆红素(r=0.4581,P<0.01)有相关性;急性肝炎血清sIgA与ALT(r=0.4692,P<0.01)、总胆红素(r=0.4265,P<0.01)有相关性.结论:检测粪便中和血清中IgA和sIgA对肝脏的临床诊断有重要的临床意义.
AIM： To investigate the values of IgA and slgA detection in the clinical diagnosis of hepatic diseases. METHODS： Patients with acute hepatitis （AH, n = 35）, chronic severe hepatitis （CSH, n = 9）, chronic hepatitis （CH, n = 67） and liver cirrhosis （LC, n = 57） were involved. The level of IgA was assayed by rate nephelometry, and the level of slgA was detected by radioimmunoassay. RESULTS： The levels of fecal IgA and slgA were no- tably elevated in patients with AH, CSH, CH and LC as compared with those in the controls （IgA： 100±47, 251±178, 80±24, 145±164 mg/L vs 〈67 mg/L, P 〈0.01; sIgA： 88±96, 326±237, 88±121, 104±109 mg/L vs 13±10 mg/L, P 〈0.01）. IgA was positively correlated with slgA（r = 0.4371, P 〈0.01）. The levels of serum IgA and slgA were markedly increased in patients with AH, CSH, CH and LC as compared with those in the controls （IgA： 3.1±1.1, 3.4±1.8, 3.3±1.7, 4.9±3.3 g/L vs 1.6±0.2 g/L, P 〈0.01; sIgA： 31.1±25.8, 80.3±25.4, 30.5±24.1, 50.0±20.5 μg/L vs 23.4±8.2 μg/L, P 〈0.01 or P 〈0.05）. The fecal IgA and slgA were not correlated with serum IgA and slgA, and serum IgA was not correlated with serum slgA （P 〉0.05）. In patients with CH, CSH and LC, serum slgA was significantly correlated with alkaline phosphatase （r = 0.523 0, P 〈0.01） and total bilirubin （r = 0.4 581, P 〈0.01）. In patients with AH, serum slgA level was correlated with alanine aminotransferase （r = 0.4 692, P 〈0.01）, total bilirubin （r= 0.4 265, P〈0.01）. CONCLUSION： The detection of IgA and slgA can be used in the clinical diagnosis of hepatic diseases.
出处
《世界华人消化杂志》
CAS
北大核心
2005年第18期2275-2277,共3页
World Chinese Journal of Digestology
