摘要
目的:评价前一周期行体外受精(IVF)失败和受精率低后,改行卵细胞胞质内单精子注射(ICSI)的受精效果。方法:行ICSI治疗的113例患者136周期分为两组:因严重少弱精子症而行ICSI的106个周期(组1);因前次常规IVF受精失败或受精率低于20%而改行ICSI的30个周期(组2)。比较两组间卵母细胞的正常受精率、优质胚胎率和妊娠率的差异,并对第2组受精率的分布进行分析,以了解改行ICSI后受精效果的改善情况。结果:改行ICSI后,两组的正常受精率和优质胚胎率差异均无显著性(70.49%vs72.02%;38.28%vs38.81%)(P>0.05)。两组的临床妊娠率分别为40.57%和40.00%,差异也无显著性(P>0.05)。改行ICSI后,大部分周期(70.00%,21/30)的受精率都在50%以上,平均受精率为79.79%,受精效果得到明显改善。结论:IVF受精失败和受精率低可以通过行ICSI而获得较好结局。
Objective： To evaluate whether or not intracytoplasmic sperm injection （ ICSI can improve previous fertilization limitation on conventional in vitro fertilization （IVF）. Methods： One hundred and thirty-six eompleted cycles in 113 patients with ICSI treatment were grouped. Group 1 was 106 cycles perform ICSI because of male factor, and group 2 was other 30 cycles with the history of fertilization failure and fertilization rate 〈 20% on conventional IVF, also assembling the cycles in group 2 according to the fertilization rate. Results ： There was no significant difference between two groups in the rates of normal fertilization（70.49% vs 72.02% ）, good quality embryos （38.28% vs 38.81% ）, and clinical pregnancy （40.57% vs 40.00% ） （P 〉0, 05 ）. The fertilization rate of a majority of cycles （70.00% , 21/30） in group 2 was higher than 50% , and the mean of fertilization rates was 79.79%. Conclusion ： ICSI can improve the fertilization limitation following IVF during previous cycles, and the fertilization rates was similar to those treated ICSI because of male factor. Natl J Androl,2005 ,11 （ 12 ） ：895-896,899
出处
《中华男科学杂志》
CAS
CSCD
2005年第12期895-896,899,共3页
National Journal of Andrology
基金
江苏省科技厅社会发展基金(BS2003045)
江苏省卫生厅生殖医学135重点学科基金
关键词
不育
体外受精
受精率低
受精失败
卵细胞胞质内单精子注射
in vitro fertilization
low fertilization rate
fertilization failure
intracytoplasmic sperm injection
