摘要
目的研究蛆虫对糖尿病足部溃疡创面的清创和抗菌作用。方法以糖尿病足溃疡创面上分离培养出的金黄色葡萄球菌为指示菌,提取丝光绿蝇幼虫血淋巴分泌物,采用平板法做抑菌实验,头孢哌酮盐水溶液做对照,记录对细菌的抑制效果。对临床上6例糖尿病足部溃疡患者行蛆虫清创治疗,观察创面情况。结果蝇幼虫分泌物对金黄色葡萄球菌,有较强的抗菌活性。6例糖尿病足部溃疡病例平均治疗12天,创面坏死组织均清除干净,新鲜的肉芽组织生长,创面培养无细菌生长。结论蛆虫对糖尿病足部溃疡创面,有较强的清创和抗菌作用。
Objective To research the antibacterial and cleaning function of maggot therapeutics for repairing foot ulcer of diabetes mellitus. Methods Using staphylococcus aureus as the indicator organisms which from the infective wound, the hemolymph secretion of the larvae was collected, the antibacterial activity was tested with disc method, recorded the antibacterial effect, cefoperazone sodium as the contrast groups. 6 cases suffered from foot ulcer of diabetes mellitus were treated with maggot therapeutics, and the exchanges of wound surface were observed. Results The secretion of the larvae had the stronger antibacterial activity on Staphylococcus aureus. Average cure period was 12 days, fresh tissue devel- oped, necrosis tissue cleaned, no bacterium existed on the ulcer surface after bacterium culture. Conclusion maggot thera- peutics has effective antibacterial and wound cleaning function on foot ulcer of diabetes mellitus.
基金
国家自然科学基金资助项目(30471786)
辽宁省自然科学基金资助项目(20042124)
关键词
蛆虫
糖尿病
溃疡
Maggot
Diabetes mellitus
Ulcer
