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黏蛋白和血管内皮生长因子在胃癌及癌前病变中的表达及意义 被引量：2

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摘要 蛋白黏液素MUC2是一种分泌性糖蛋白,在正常胃黏膜中不表达,当胃黏膜出现肠化或恶变时有表达.血管内皮生长因子(VEGF)是调节新血管生成的最重要因子,而新的血管生成是肿瘤生长、转移和转移灶生长的必要条件.本研究采用免疫组化SP法检测胃癌组织、肠化生黏膜、正常胃黏膜中MUC2和VEGD的表达,以观察其在胃癌发生发展中的作用及与胃癌生物学行为的关系.
作者 张玉英 丰义宽 李国庆 张居民 孙善明
机构地区 潍坊医学院附属潍坊市人民医院消化科
出处 《中华消化杂志》 CAS CSCD 北大核心 2005年第10期628-629,共2页 Chinese Journal of Digestion
关键词 血管内皮生长因子(VEGF) 胃癌组织 黏蛋白 癌前病变 免疫组化SP法 新血管生成 癌生物学行为 MUC2 胃黏膜 重要因子
分类号 R735.2 [医药卫生—肿瘤]
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参考文献4

  • 1Moniaux N, Escande F, Porchet N, et al. Structural organization and classification of the human mucin genes. Front Biosci, 2001,6:1192-1206.
  • 2汪荣泉,房殿春,刘为纹.胃癌及癌前病变组织中MUC2基因的表达[J].世界华人消化杂志,2000,8(3):285-288. 被引量：31
  • 3Reis CA, David L, Correa P, et al. Intestinal metaplasia of human stomach displays distinct patterns If mucin(Mucl, Muc2,Muc5AC, Muc6)expression. Cancer Res, 1999, 59: 1003-1007.
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二级参考文献7

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共引文献30

同被引文献15

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中华消化杂志
2005年 第10期

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