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MPTP帕金森病动物模型研究进展 被引量：13

Progress in MPTP-Induced Animal Models of Parkinson's Disease
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摘要 用神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)制备的动物模型,无论在神经生化和病理组织学特征,还是在运动行为表现方面都酷似人帕金森病(PD),是目前研究PD的理想模型。对MPTP动物模型发病机制等方面的深入研究将有助于PD的防治。 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine （ MPTP）-induced animal models are ideal models of human Parkinson＇ s disease, in terms of neurobiochemical and histopathological changes, as well as behavioral disorders., Intensive research into the pathogenesis and other fields of MPTP-induced lesions in the animal models will contribute much to the prevention and cure of human Parkinson＇s disease.
作者 高云朝 林祥通
机构地区 复旦大学附属华山医院核医学科
出处 《中国实验动物学报》 CAS CSCD 2005年第4期261-265,共5页 Acta Laboratorium Animalis Scientia Sinica
关键词 帕金森病 1-甲基-4-苯基-1 2 3 6-四氢吡啶 模型 动物 Parkinson＇s disease 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine Model, animal
分类号 R741 [医药卫生—神经病学与精神病学] Q95 [生物学—动物学]
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参考文献31

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二级参考文献34

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共引文献66

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中国实验动物学报
2005年 第4期

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