摘要
目的探讨CT导向下125I粒子植入联合髂内动脉化疗灌注治疗盆腔肿瘤复发的临床疗效。方法总结8例盆腔复发肿瘤采用CT导向下125I放射性粒子植入联合髂内动脉化疗灌注患者的疗效。所有患者术前或术后给髂内动脉灌注化疗,化疗方案根据原发肿瘤的类型确定。粒子植入之前采用TPS模拟布源或遵循Halarism的125I经验公式:mCi=Da×5,Da为靶组织长、宽、高的平均值(L+W+H)/3,单位为cm,求出术中所需125I粒子的总活度及算出治疗粒子的数量。在螺旋CT导向下将125I放射性粒子植入盆腔肿瘤内。结果全组8例患者8个病灶2个月后采用PET-CT评价,完全缓解(CR)0例,部分缓解(PR)5例,稳定(NC)2例,进展(PD)1例,全组病例随访1年,死亡2例,其余6例存活,最长的生存时间15个月。结论125I放射性粒子植入联合髂内动脉灌注化疗是治疗盆腔肿瘤复发的一种有效的方法。
Objective to explore the clinical value of seeds implantation technique under CT guidance, combined with internal iliac arterial infusion chemotherapy in the treatment of recurrence pelvic tumors. Methods Eight patients with recurrence pelvic tumors have been treated by ^125Ⅰ seeds implant combined with internal iliac arterial infusion chemotherapy. The chemotherapy scheme was based on the primary tumor type. Under CT guidance,^125Ⅰ seeds were implanted into the pelvic tumors according to TPS or Halarism＇ s experienced function： mCi = Da × 5 （Da means the average of length, width and height of the lesion）, mCi is the total activity of ^125ⅠI. The number of^125Ⅰ seeds fieeded equals to that of total activities divided by the activity of single particle. Results All the patients received PET-CT chest follow up two months later. CR, PR, NC, PD were abtained in 0,5,2, 1 cases respectively. Two patients died within one year, other 6 patients are still alive, the longest survival period was more than 15 months, the l-year survival rates was 75%. Conncluslons ^125Ⅰ seeds implant combined with internal iliac arterial infusion chemotherapy is an effective method in the treatment of pelvic recurrence tumors.
出处
《介入放射学杂志》
CSCD
2005年第6期610-612,共3页
Journal of Interventional Radiology
关键词
盆腔肿瘤
放射性粒子
化疗灌注
Pelvic tumors
^125Ⅰradioactive seeds
Infusion chemotherapy
