摘要
目的观察5-FU持续输注联合顺铂腹腔灌注治疗晚期胃肠道肿瘤客观疗效及毒副作用。方法深静脉留置导管,CF 200mg/m2输注后5-FU 3.5g/m2置入微泵持续输注48小时,同时用DDP 60mg/m2行腹腔化疗。结果52例病人,CR 6例,PR 22例,SD 21例,PD 3例,总有效率53.9%。其中胃癌32例,CR 5例,PR 15例,有效率62.5%;肠癌20例,CR 1例,PR 7例,有效率40.0%。主要毒副反应为恶心呕吐、骨髓抑制,大多为I^II级。结论5-FU持续输注联合顺铂腹腔灌注治疗晚期胃肠道肿瘤近期疗效较好,可减轻临床症状,毒副反应较轻。
Objective To evaluate the efficacy and toxicity of the combination of cantinuous infusional 5 - fluorouracil with intraperitioneal cisplatin chemotherapy in the treatment of advanced gastrointestinal tumor. Methods All patients were treated with CF 200mg/m^2, followed by 5 - FU （3.5g/m^2 ） as a 48 - hour continuous infusion by the minute pump and intraperitioneal cisplatin（60mg/m^2 ） chemotherapy. Results A total of 52 patients were included in this study , there were 6 CR , 22 PR , 21 SD and 3 PD, overall response rate 53.9%. In those patients, 22 had gastric carcinoma , 5 patients CR , 15 patients PR , response rate was 62.5% ; 20 had intestine carcinoma, there were 1 patients CR , 7 patients PR , response rate was 40.0%. The most frequent toxicity （ grade Ⅰ - Ⅱ ） were nausea/vomiting and bone marrow depression. Conclusion The therapeutic efficacy of continuous infusional 5 - fluorouracil with intraperitioneal cisplatin chemotherapy in the treatment of advanced gastrointestinal tumor is satisfactory. It can decrease clinical related symptoms significantly and the toxicity is mild .
出处
《现代肿瘤医学》
CAS
2006年第1期63-65,共3页
Journal of Modern Oncology
关键词
晚期胃肠肿瘤
持续输注化疗
腹腔化疗
advanced gastrointestinal tumor
continuous infusional chemotherapy
intraperitioneal chemotherapy
