摘要
目的对冠状动脉结扎致大鼠急性心肌缺血模型的中医证型进行反证研究。方法采用冠脉结扎法复制大鼠急性心肌缺血模型,依活血祛瘀、通阳散结、回阳益气、益气养阴不同治法选择经典复方失笑散、瓜蒌薤白白酒汤、参附汤和生脉散,对临床最常见的冠心病(胸痹)证型进行比较研究,观察各组方药对超氧化物歧化酶(SOD)、丙二醛(MDA)、血栓素(TXB2)及6酮前列腺素F1α(6-keto-PGF1α)等指标的影响。结果中医治疗各组均有一定的疗效,均能提高SOD、6-keto-PGF1α的水平,降低MDA、TXB2的水平。综合各组的整体疗效,其中尤以失笑散组最为显著,与模型组相比差异有显著性(P<0.05,P<0.01),瓜蒌薤白白酒汤组次之,参附汤组和生脉散组与模型组相比无显著性差异(P>0.05)。结论以冠脉结扎法建立的大鼠急性心肌缺血模型具有心血瘀阻的性质,今后的研究涉及胸痹心血瘀阻证型,似可采用冠脉结扎法造模。
To study the syndrome pattern of rats with acute myocardial ischemia （AMI）induced by ligation of coronary artery（LCA） through different treatments. Methods Rat models with acute myocardial ischemia were established by ligation of coronary arteries. 60 rats were randomized into 6 groups. Group A was treated with Shixiao Powder（ SXP）, group B with Gualou Xiebai Decoction（ GLXD）, group C with Shenfu Decoction（SFD） and group D with Shengmai Decoction（SMD）.Each group was treated for 2 weeks. Other 2 groups were regarded as control group and sham-operated group. Thromboxane B2 （ TXB2 ）, 6-keto-PGF1α, superoxide dismutase （SOD） and malondialde hyde（MDA） were observed. Results After treatment, the levels of SOD and 6-keto-PGF1αwere increased and the levels of MDA, TXB2 were decreased in all treatment groups, while the effect of Shixiao Powder is most remarkable, compared with control group（ P 〈0.05 or P 〈0.01 ）, followed by Gualou Xiebai Decoction（P 〈 0.05 ）. Group C and group D have no significant difference compared with control group （P 〉 0. 05）. Conclusion The model of acute myocardial ischemia induced by ligation of coronary artery shows the characters of heart-blood stasis.
出处
《上海中医药大学学报》
CAS
2005年第4期36-38,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
关键词
冠状动脉结扎
心肌缺血
动物模型
中医疗法
中医证型
Ligation of coronary artery
acute myocardial ischemia
animal model
Chinese Medicine
syndrome pattern
