4Rtledge DR,Garrick C. Determination of metoprolol and its α- Hydroxide metabolite in serum by reversed-phase high performance liquid chromatography. J Chromatogr, Sci, 1989,27(9) :561.
5Be al JL, Tett SE. Determination of pindolol enantiomers in human plasma and urine by simple liquid-liquid extraction and high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl, 1998,715(2): 409
6P. Dayer,T. Leemann,A. Marmy,J. Rosenthaler. Interindividual variation of beta-adrenoceptor blocking drugs, plasma concentration and effect: Influence of genetic status on behaviour of atenolol, bopindolol and metoprolol[J] 1985,European Journal of Clinical Pharmacology(2):149～153
7M. Larsson,S. Landahl,P. Lundborg,C. G. Reg?rdh. Pharmacokinetics of metoprolol in healthy, elderly, non-smoking individuals after a single dose and two weeks of treatment[J] 1984,European Journal of Clinical Pharmacology(2):217～222
5Rtledge DR, Garrick C. Determination of metoprolol and its a-Hydroxide metabolite in serum by reversed phase high performance liquid chromatography[J].J Chromatogr Sci, 1989,27(9) :561.
6Howell S J, Sear YM, Yeates D, et al.Risk factors for card- chovascular death after elective surgery under general ana- ethesta[J].Br JAnaesth, 1998,80( 1 ) : 14.
7Allman KG, muir AD, HWell S J, et al, resistant hyperten- tion and preoperative silent myocarchal ishemia in surgi- cal patients[J].Br JAnaesth, 1998,80 (1) : 14.
8Stuhmeier KD, Maizer B, Cierpka J, et al.smalloral dose of clonidine reduce the incidence of intraoperative myo- carchal ischemia in surgical patients having vascular sur- gery[J].Aneshesiology, 1996,85 (4) : 706.
9Poldermans D, Boersma E, Bax JJ, et al. The effect ofbi- soprolol on perioperative mortality and myocardial infarc- tion in high- risk patients undergoing vascular surgery. [J]. NEngIJMed, 1999,341(24) : 1 789.
10Mangano DT, Layug EL, Wallace A, et al. Effect of aten- olol on mortality and cardiovascular morbidity after non- cardiac surgery[J]. N Engl J Med, 1996,335 ( 23 ) : 1 713.
