摘要
目的将恩纳(eutectic mixture of local anesthetics,EMLA)涂抹在带状疱疹后遗神经痛(postherpetic neuralgia,PHN)患者的疼痛皮肤上同时并用神经阻滞,探讨治疗PHN的新方法。方法选择PHN患者40例,用随机、单盲法分成两组。Ⅰ组为试验组,Ⅱ组为对照组。Ⅰ组在疼痛部位涂抹EMLA软膏;Ⅱ组在疼痛部位涂抹红霉素软膏。两组根据疼痛部位所属的脊神经实施肋间神经阻滞或椎间孔阻滞。结果治疗1 h后VAS评分:Ⅰ组0分18例,1-3分2 例;Ⅱ组0分18例,1～3分2例。两组镇痛结果在第1 h差异无统计学意义P>0．05。治疗6-36h 后VAS评分:Ⅰ组0分9例,1-3分11例;Ⅱ组0分1例,1-3分6例,4-6分13例。两组镇痛效果在治疗6-36 h差异有统计学意义P<0．05。1个疗程后Ⅰ组治愈19例(95％),Ⅱ组治愈14例 (70％),两组治愈率差异有统计学意义P<0．05。3个月后随访Ⅰ组总有效率为100％(20例),Ⅱ组总有效率为90％(18例)。两组相比差异有统计学意义P<0．05。结论 EMLA疼痛部位涂抹加神经阻滞治疗PHN比单用神经阻滞有明显的疗效。
Objective To explore a new treatment method for postherpetic neuralgia （PHN） by combining eutectic mixture of local anesthetics （EMLA） and never block. Methods Forty patients with PHN were randomly divided into two groups, 20 patients in each group. In group Ⅰ （study group）, EMLA was applied to the algetic site, and in group Ⅱ （control group） erythromycin ointment was applied to the algetic site; intercostal nerve block or foramen intervertebral block were preformed in both groups. Patients＇ VAS was recorded and follow-up for 3 months. Results The VAS were zero in 18 patients and 1-3 in 2 patients in both groups at 1 h after treatment; whereas, after 6-36 h, the VAS was still zero in 9 patients and 1-3 in 11 patients in group Ⅰ, but the VAS was zero in only 1 patient, 1-3 in 6 patients and 4-6 in 13 patients in group Ⅱ, there were statistic differences between the two groups. After one course of treatment, the cure rate was 95%（19 patients） in group Ⅰ and 70%（14 patients） in group Ⅱ; follow-up 3 months, the effective rate was 100 % （20 patients） and 90 % （ 18 patients） in group Ⅰ and in group Ⅱ respectively; both have statistic differences in the two groups. Conclusion Local application of EMLA plus nerve block are more effective for treatment of PHN.
出处
《实用疼痛学杂志》
2006年第1期16-18,共3页
Pain Clinic Journal
关键词
恩纳
神经传导阻滞
疱疹
带状
神经痛
Eutectic Mixture of Local Anesthetics
Nerve Block
Herpes Zoster
Neuralgia
