摘要
目的评价新型L/DL聚乳酸(PLDLA)接骨材料在实验动物体内的降解特性。方法新西兰白兔下颌骨造成骨折,采用PLDLA接骨材料行内固定术。术后1、24、、8周分别观察PLDLA接骨板大体降解情况、测试三点弯曲强度、检测分子质量等,观察PLDLA材料在体内的降解吸收速度。结果实验动物下颌骨骨折断端均对位良好。随时间推移PLDLA接骨板出现明显降解,其降解过程与骨折的愈合过程基本符合。结论PLDLA接骨板、螺钉对兔下颌骨骨折均具有良好的内固定作用,符合骨折内固定的基本要求。PLDLA的降解速度与骨折愈合速度基本相符,但相对于周围组织清除能力则降解稍显过快。
Objective To investigate the degradation of poly （L/DL-Lacfide）（PLDLA）internal fixation devices in vivo. Methods The models of mandibular body fracture were created and fixed with PLDLA plates and screws. The rabbits were sacrificed at 1,2,4,8 weeks after operation, The molecular weight and mechanics of PLDLA plates were investigated. Results Bony union was excellent. The PLDLA plates were gradually absorbed with time going on during observation, Conclusion PLDLA plates can be gradually biodegraded in vivo, which is correspondent with the fracture-healing process.
出处
《口腔医学》
CAS
2005年第6期370-372,共3页
Stomatology
