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复方双氯芬酸钠注射液中双氯芬酸钠和对乙酰氨基酚的HPLC测定 被引量:3

Determination of Diclofenac Sodium and Paracetamol in Compound Diclofenac Sodium Injection by HPLC
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摘要 建立了HPLC法同时测定复方双氯芬酸钠注射液中双氯芬酸钠和对乙酰氨基酚的含量。采用C18柱,甲醇-5%乙酸溶液(80∶20)为流动相,检测波长275nm。双氯芬酸钠和对乙酰氨基酚分别在8~128μg/ml和32~512μg/ml浓度范围内线性关系良好。平均回收率分别为100.2%和99.3%,RSD分别为0.76%和0.50%。 A HPLC method was established for simultaneous determination of diclofenac sodium and paracetamol in compound diclofenac sodium injection. A C18 column was used with the mobile phase of methanol - 5 % acetic acid solution (80; 20) at the detection wavelength of 275nm. The calibration curves of diclofenac sodium and paracetamol were linear in the concentration ranges of 8 - 128μg/ml and 32 - 512μg/ml, respectively. The average recoveries were 100.2 % and 99.3 %, with RSDs of 0.76% and 0.50%, respectively.
作者 杨芳 岳永波
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第1期39-40,共2页 Chinese Journal of Pharmaceuticals
关键词 双氯芬酸钠 对乙酰氨基酚 高效液相色谱 测定 diclofenac sodium paracetamol HPLC determination
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