摘要
目的评价羟基喜树碱（HCPT）联合FOLFOX4方案治疗晚期胃癌、大肠癌的近期疗效和毒副反应。方法28例晚期消化道癌患者，先给予草酸铂（L—OHP）85mg／m^2静脉点滴2h d1，亚叶酸钙（CF）200mg／m^2静脉点滴2h d1～d2，随后5-氟尿嘧啶（5-FU）400mg／m^2静脉推注，5-FU 600mg／m^2静脉点滴22h d1—d2，同时给予HCPT6mg／m^2静脉点滴3h d1—d3。2周重复，4周期后评价疗效。结果全组28例，其中完全缓解（CR）2例（7．1％），部分缓解（PR）16例（57．1％），稳定（SD）4例（14．3％），进展（PD）6例（21．4％）。总有效率（CR＋PR）64．3％。胃癌16例，11例有效，有效率68．8％。大肠癌12例，7例有效，有效率58，3％。毒副反应主要是恶心呕吐，白细胞减少，神经感觉毒性，无化疗相关死亡。结论HCPT联合FOLFOX4方案治疗晚期消化道癌疗效肯定，毒副反应能耐受。
Objective To study the response and toxicity of the regimen of hydroxycamptothecin（ HCPT ） combined with biweekly regimen of leucovorin （ CF ）, 5 - fluorouracil （ 5 - FU ） and oxaliplatin （ L - OHP ） （ named FOL- FOX4 regimen ） in treat -ment of advanced gastrointestinal cancers.Mthods Twenty eight patients with advanced gastvointestinal cancer received chemotherapy of regimen L - OHP 80mg/m^2 hours iv on dayl, CF 200 mg/m^2 2 hours iv on day I to 2, followed by 5 - FU 400 mg/m^2 iv and 600 mg/m^2 22 hours on day I to 2. HCPT6 mg/m^2 iv 3 hours on day 1 to 3, two weeks as one cycle . Efficacy was evaluated after 4 cycles. Results Two patients achieved complete response （CR） , 16 patients partial response （PR） ,4 patients stable disease （SD） ,6 patients progression disease （ PD）. Overall response rate was 64.3%. Response rate was 68.8% in advanced gastric cancer. Response rate was 58.3% in advanced colorectal cancer. The major toxicity included nausea ,vomiting, leucopenia and neuro - sensory. There were no any death during treatment. Conclusion This study shows that the regimen of HCPT combined with FOLFOX4 is effective and tolerable in advanced gastrointestinal cancer.
出处
《现代肿瘤医学》
CAS
2006年第2期201-202,共2页
Journal of Modern Oncology
关键词
羟基喜树碱
草酸铂
氟尿嘧啶
亚叶酸钙
化学治疗
hydroxycamptothecin
oxaliplatin
5 - fluorouracil
leucovorin
chemotherapy
