摘要
为研究普罗帕酮对短期电重构后清醒山羊心房的电生理特性的影响,探讨其抗心律失常作用的可能机制,在7只山羊的左房游离壁外膜缝合4对电极,经皮下隧道将电极导线引至颈部皮肤外。术后2周测量不同基础刺激周长(BCL)时的心房有效不应期(AERP)、BCL为200ms时的心房传导速度(CV)并计算心房波长(WL)。心房快速刺激维持心房颤动(简称房颤)6h后静脉滴注(简称静滴)生理盐水,重复上述指标测量。2天后,在房颤6h后静滴普罗帕酮,重复上述测量。结果:①在基础状态下,AERP表现出频率适应性;②6h的房颤后,在静滴生理盐水时,AERP的频率依赖特性丧失。BCL为200ms时,AERP及WL均缩短,CV变化不显著;③在静滴普罗帕酮时,AERP显示使用依赖特性。BCL为200ms时,与基础状态时比较,AERP延长,CV及WL缩短;但与静滴盐水时相比,WL无明显变化。结论:在经过6h的电重构后,普罗帕酮使AERP表现为使用依赖特性。快速心房刺激时,普罗帕酮使AERP明显延长,CV明显缩短。
The purpose of this study was to investigate＇the mechanism of propafenone （PF） ＇s antiarrhythmic action in short term electrical remodeling conscious goats. Seven goats were chronically instrumented with 4 pair of electrodes to the epicardium of left atria. Two weeks after implantation, the atrial effective refractory period （AERP） at different basic cycle length （BCL） and atrial conduction velocity（CV） at BCL of 200 ms were measured and atrial wavelength （WL） was calculated. Then atrial fibrillation （AF） was induced and maintained for 6 hours by rapid atrial pacing. After normal saline （NS） infusion, the above parameters were remeasured. Two days later, AF was maintained for 6 hours after basic state measurement. Then PF was infused and all the parameters were remeasured. Results： In basic state the physiological rate adaptation of AERP was manifested, and AERP, CV and WL at BCL of 200 ms were 142.0 ± 14.5 ms, 108.0 ± 14.4 crn/s and 15.3 ± 1.6 cm,respectively. After 6 hour＇s AF, during NS infusion, the rate adaptation of AERP was lost, and AERP, CV and WL were 125.1 ± 10.8 ms （P 〈 0.01 ）, 105.7 ± 9.5 cm/s （ P 〉 0.05） , and 13. 2 ± 1.5 cm （P 〈0.01 ）, respectively. During PF infusion following 6 hour＇s AF, AERP increased in use-dependent way; CV and WL shortened compared with basic state. But WL did not significantly change compared with NS infusion. After electrical remodeling AF could be induced in all the goats of two different states, but the AF duration was reduced during PF infusion （P 〈0.01 ）. Conclusion： After 6 hours electrical remodeling, PF can prolong AERP use-dependently. PF increases AERP and decreases CV markedly at high pacing rate.
出处
《中国心脏起搏与心电生理杂志》
2005年第6期487-489,共3页
Chinese Journal of Cardiac Pacing and Electrophysiology
基金
全军医药卫生"十五"计划科研基金(基金编号:01MB074)
关键词
电生理学
心房颤动
电重构
普罗帕酮
山羊
Electrophysiology
Atrial fibrillation
Electrical remodeling
Propafenone Goat
