摘要
目的:探讨心肌型脂肪酸结合蛋白(H-FABP)与急性心肌梗死(AM I)患者预后的关系。方法:正常对照组20例,急性心肌梗死组58例经住院期间及平均6个月的随访,观察H-FABP的变化及心血管事件发生组与未发生组的差异。结果:血清H-FABP对照组为4.2±2.3μg/L,AM I组为16.2±3.6μg/L,总心血管事件发生组为19.9±4.5μg/L,未发生组为15.8±4.9μg/L。结论:AM I急性期血H-FABP浓度显著增高,随访心血管事件发生率高的患者其H-FABP明显升高,H-FABP可作为AM I心血管事件的预测因子。
Objective：To doscuss the value of heart fatty acid binding protein（ H - FABP） in estimating risk stratification in patients with acute myocardial infarction （AMI）. Methods ：78 subjects were selected for the study,and 20 of them constituted a healthy control group and 58 of them were ones with. acute myocaridial infarction （AMI）. The blood concentrations of H - FABP were measured one day after infarction in AMI patients and the healthy controls group. The AMI patients were given an average six - mouth follow - up survey. The main outcomes were heart failure, mortality and other adverse cardial events in half a year. Results：H -FABP concentrations in patients with AMI （16.2 ±3.6μg/L）were much higher than those in the health control group（4.2 ± 2.3μg/L,P 〈 0.05 ）. The development of any of the clinical points （death/CHF/shock） occured more frequently in patients with a higher H - FABP count（ 19.9 ＋ 4.5 μg/L） than that of no clinical points （ 15.5 ＋ 4.9μg/L, P 〈 0. 05）. Conclusion：The results of the present study confirms the elevated H - FABP count is related to the risk stratification, and prognosis in patients with AMI. Elevations in H - FABP are associated with a higher incidence of adverse clinical outcome after AMI. It can serve as a strong predictor for the subsepuent development of poor outcomes in AMI patients.
出处
《南通大学学报（医学版）》
2005年第6期422-423,共2页
Journal of Nantong University(Medical sciences)
