期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

NHE1在心肌肥大,心肌纤维化和心衰中的作用 被引量：6

原文传递
导出
摘要 心肌肥大、心肌纤维化是多种慢性心衰的共同病理学改变,钠氢交换体1(NHE1)是多种因子介导的心肌肥大和心肌纤维化的信号转导通路上的共同途径,直接参与了其病理生理学过程,这些因子包括多种生长因子、肾上腺素能受体激动剂、血管紧张素、内皮素、凝血酶以及直接作用于细胞上的机械性张力。从理论推理和实验学证据两方面研究NHE1参与心肌肥大、纤维化和心衰的机制具有重要的意义。
作者 金振晓 辛梅 陈涛 周京军
机构地区 中国人民解放军第四军医大学附属西京医院心脏外科 中国人民解放军第四军医大学基础部生理学教研室
出处 《国际病理科学与临床杂志》 CAS 2005年第6期536-538,共3页 Journal of International Pathology and Clinical Medicine
关键词 心肌 钠氢交换体(NHE1) 心力衰竭 纤维化 肥大
分类号 R542.2 [医药卫生—心血管疾病] R541.6 [医药卫生—心血管疾病]
  • 相关文献

参考文献23

  • 1Nath SK, Hang CY, Levine SA, et al. Hyperosmolarity inhibits the Na^ +/H ^+ exchanger isoforms NHE2 and NHE3: an effect opposite to that on NHE1 [ J]. Am J Physiol, 1996,270 (3Ptl) : G431-G441.
  • 2Denker SP, Barber DL. Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1 [ J]. J Cell Biol ,2002 ,159 ( 6 ) : 1087-1096.
  • 3Putney LK, Barber DL. Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition [ J]. J Biol Chem,2003, 278(45 ) :44645-44649.
  • 4Putney LK, Denker SP, Barber DL. The changing face of the Na^+/H^+ exchanger, NHEI: structure, regulation, and cellular actions[ J]. Annu Rev Pharmacol Toxicol,2002,42( ) :527-552.
  • 5Wang H, Silva NL, Lucchesi PA, et al. Phosphorylation and regulation of the Na ^+/H^+ exchanger through mitogen-activated protein kinase[J]. Biochemistry,1997, 36(30) :9151-9158.
  • 6Woo SH, Lee CO. Effects of endothelin-1 on Ca^2 + signaling in guinea-pig ventricular myocytes : role of protein kinase C [ J ]. J Mol Cell Cardiol, 1999, 31(3) : 631-643.
  • 7Moor AN, Fliegel L. Protein kinase-mediated regulation of the Na^+ /H^+ exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways [ J ]. J Biol Chem, 1999, 274 ( 33 ) :22985-22992.
  • 8Grinstein S, Woodside M, Sardet C, et al. Activation of the Na^+/H^+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism [ J ]. J Biol Chem, 1992, 267(33) : 23823-23828.
  • 9McSwine RL, Li J, Villereal ML. Examination of the role for Ca^2+ in regulation and phosphorylation of the Na ^+/H^+ antiporter NHE1 via mitogen and hypertonic stimulation [ J ]. J Cell Physiol , 1996,168(1): 8-17.
  • 10Denker SP, Huang DC, Orlowski J, et al. Direct binding of the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H^+ translocation [ J ]. Mol Cell,2000, 6(6) : 1425-1436.

同被引文献62

  • 1苗茜,闵苏.钠/氢离子交换抑制剂心保护研究进展[J].中国体外循环杂志,2005,3(1):53-56. 被引量：1
  • 2Nakamura T Y,Iwata Y,Arai Y,et al.Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure[J].Circ Res,2008,103(8):891-899.
  • 3Von Lewinski D,Stumme B,Fialka F,et al.Functional relevance of the stretch-dependent slow force response in failing human myocardium[J].Circ Res,2004,94(10):1392-1398.
  • 4Ennis I L,Escudero E M,Console G M,et al.Regression of isoproterenol-induced cardiac hypertrophy by Na+/H+ exchanger inhibition[J].Hypertension,2003,41(6):1324-1329.
  • 5Hayasaki-kajiwara Y,Kitano Y,Iwasaki T,et al.Na+ influx via Na+/H+ exchanger activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes[J].J Mol Cell Cardiol,1999,31(8):1559-1572.
  • 6Nakamura T Y,Iwata Y,Arai Y,et al.Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure[J].Circ Res.2008,103(8):891-899.
  • 7Kemp G,Young H,Fliegel L.Structure and function of the human Na+/H+ exchanger isoform 1[J].Channels,2008,2(5):329-336.
  • 8Ho K K,Pinsky J L,Kannel W B,et al.The epidemiology of heart failure:the Framingham Study[J].J Am Coll Cardiol,1993,22(4 Suppl A):6-13.
  • 9Hisamitsu T,Yamada K,Nakamura T Y,et al.Functional importance of charged residues within the putative intracellular loops in pH regulation by Na+/H+exchanger NHE1[J].FEBS J,2007,274(16):4326-4335.
  • 10Cingolani H E,Rebolledo O R,Portiansky E L,et al.Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition[J].Hypertension,2003,41(2):373-377.

引证文献6

二级引证文献14

国际病理科学与临床杂志
2005年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部